Visible-Light Mediated Functionalization in Phe-Containing Peptides Upon a Debenzylative Amination Process.
Resumen
No hay resumen
Category Archives: 2026
Torres-Oya et al. Org Biomol Chem. 2026;24(8):1690-1696. Enantioselective copper(II) catalysed (4+2) cycloaddition of aza-o-quinone.
Publications > Torres-Oya et al
Enantioselective copper(II) catalysed (4 %@2B 1) cycloaddition of aza-o-quinone.
Universidad de Alcalá (IRYCIS), Departamento de Química Orgánica y Química.
Abstract
Optically active indolines are valuable structural motifs present in numerous naturally occurring and biologically active molecules. Although several methodologies have been reported in the literature for the synthesis of chiral indolines, many of them rely on the hydrogenation of indoles using expensive metal catalysts. In this report, a copper(II)-catalysed enantioselective (4 %@2B 1)
Mañas and. Eur J Med Chem. 2026;307:118648. Aliphatic azo compounds as programmable nitrogen donors in alkyne-mediated.
Aliphatic azo compounds as programmable nitrogen donors in alkyne-mediated.
Universidad de Alcalá, Departamento de Química Orgánica y Química Inorgánica.
Keywords: Aliphatic azo compounds; Azo-alkyne cycloadditions; Heterocycle synthesis; Nitrogen donors; Nitrogen transfer; Pyrazoles; Pyrroles
Abstract
Nitrogen-containing heterocycles constitute the core of many approved drugs and
Mañas and. Trends in Chemistry. 2026;8(2):149. Divergent heterocycle synthesis enabled by switchable reaction of azobenzenes with alkynes.
Divergent heterocycle synthesis enabled by switchable reaction of azobenzenes with alkynes.
Resumen
Azobenzenes are long-standing photochromic switches now emerging as synthetic reagents.Their reactions with alkynes enable efficient access to diverse nitrogen heterocycles.Distinct activation modes (metal, photoredox, thermal) dictate divergent reaction pathways.Mechanistic studies reveal complementary polar and radical manifolds.This reactivity opens new opportunities in drug discovery and molecular materials.
Tostado et al. Org Biomol Chem. 2026;24(1):80-86. Selective synthesis of 4,5-dihydropyrenes by a Brønsted acid-catalyzed.
Selective synthesis of 4,5-dihydropyrenes by a Brønsted acid-catalyzed.
Universidad de Alcalá (IRYCIS). Departamento de Química Orgánica y Química.
Abstract
A metal-free Brønsted acid-catalyzed cascade cyclization enables the selective
García-García et al. Org Lett. 2026;28(3):907-911. Synthesis of Multisubstituted Pyridines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Caerulomycins A and K.
Publications > García-García et al
Synthesis of Multisubstituted Pyridines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Caerulomycins A and K.
Departamento de Química Orgánica y Química Inorgánica, Instituto de Investigación Química "Andrés M. del Río" (IQAR), Universidad de Alcalá, IRYCIS, 28805 Alcalá de Henares, Madrid, Spain.
Abstract
A concise synthesis of multisubstituted pyridines from α-allylic TosMIC derivatives and electrophiles is reported. The process involves a tandem heterocyclization exploiting the dual reactivity of the isocyanide group. The methodology tolerates various electrophiles, including halogen sources, and proceeds under mild conditions. Its utility is showcased in the total synthesis of caerulomycins A and K, in only five steps from TosMIC.