Jaime Mateos-Gil, Marcos Humanes, Manuel A. Fern\u00e1ndez-Rodr\u00edguez,* Patricia Garc\u00eda-Garc\u00eda*<\/p>\n
Metal-free borylative cyclizations of alkynes have emerged as a powerful and versatile strategy for the construction of boron-containing cyclic frameworks. By exploiting the electrophilic activation of alkynes with boron Lewis acids, these transformations enable intramolecular nucleophilic attack rendering the simultaneous formation of C–<\/span>B and C–<\/span>C or C–<\/span>X bonds under mild, transition-metal-free conditions. While early examples relied on B(C6<\/sub>F5<\/sub>)3<\/sub>\u00a0and delivered products of limited synthetic utility, recent developments based primarily on ClBcat and BCl3<\/sub>\u00a0have greatly expanded the scope and practical relevance of these reactions. A wide range of heteroatom- and carbon-based nucleophiles can be engaged, providing access to diverse borylated hetero- and carbocycles, typically isolated as versatile boronate esters. This review summarizes recent advances in this rapidly developing field and reveals future opportunities for expanding molecular diversity through rational substrate design.<\/p>\n Chem. Rec. 2026 Metal-Free Electrophilic Borylative Cyclizations of Alkynes Jaime Mateos-Gil, Marcos Humanes, Manuel A. Fern\u00e1ndez-Rodr\u00edguez,* Patricia Garc\u00eda-Garc\u00eda* Metal-free borylative cyclizations of alkynes have emerged as a powerful and versatile strategy for the construction of boron-containing cyclic frameworks. By exploiting the electrophilic activation of alkynes with boron Lewis acids, these transformations enable intramolecular nucleophilic attack rendering the simultaneous … Continue reading Chem. Rec. 2026<\/span>
\nDOI: http:\/\/doi.org\/10.1002\/tcr.202500356<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"