{"id":4307,"date":"2026-04-30T14:05:09","date_gmt":"2026-04-30T14:05:09","guid":{"rendered":"https:\/\/quibio.web.uah.es\/group\/?p=4307"},"modified":"2026-04-30T14:05:21","modified_gmt":"2026-04-30T14:05:21","slug":"chem-sci-2026","status":"publish","type":"post","link":"https:\/\/quibio.web.uah.es\/group\/chem-sci-2026\/","title":{"rendered":"Chem. Sci. 2026"},"content":{"rendered":"<h1 class=\"citation__title\">Enantioselective synthesis of configurationally stable [5]helicenes containing 1,2-azaborine units<\/h1>\n<p>Catherine Olguin, Christian Tabacaru, Lennart Besse, Martin Simon, Christopher Golz, Marcos Humanes, Manuel A. Fern\u00e1ndez-Rodr\u00edguez, Patricia Garc\u00eda-Garc\u00eda,* Maike M\u00fccke, Ricardo A. Mata* and Manuel Alcarazos*<\/p>\n<p>Two different families of BN-doped [5]helicenes have been efficiently synthesized through a highly enantioselective, intramolecular, Au-catalyzed alkyne hydroarylation reaction. Key for the success of the method is the use of BINOL-derived cationic phosphonites as ancillary ligands (BINOL: 1,1-bi-2-naphthol). The inversion barriers of the structures obtained have been determined both experimentally and theoretically, and are essentially identical to those reported for non-dopped carbo[5]helicenes of otherwise identical structure. Contrarily, the newly prepared BN-doped helicenes exhibit intensified absorption spectra at long wavelength (\u03bb \u2248 400 nm) and fluorescence when compared with their only-carbon counterparts. These effects are particularly pronounced for the naphtho[2,1-c]phenanthro[1,2-e][1,2]azaborinine series, in which the BN-unit is located at the rim of the helix. Preliminary studies on the post-synthetic functionalization of these structures are also described; specifically, the naphtho[2,1-c]phenanthro[1,2-e][1,2]azaborinine structure can be site-selective brominated at position 4. In addition, the unprecedented deborilation of these helices to afford axially chiral anilines has been observed by treatment with DDQ.<\/p>\n<p>Chem. Sci. 2026<br \/>\nDOI: <a class=\"text--small\" title=\"Link to landing page via DOI\" href=\"https:\/\/doi.org\/10.1039\/D6SC02344D\">https:\/\/doi.org\/10.1039\/D6SC02344D<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4308\" src=\"https:\/\/quibio.web.uah.es\/group\/wp-content\/uploads\/2026ChemSci.png\" alt=\"\" width=\"649\" height=\"228\" srcset=\"https:\/\/quibio.web.uah.es\/group\/wp-content\/uploads\/2026ChemSci.png 649w, https:\/\/quibio.web.uah.es\/group\/wp-content\/uploads\/2026ChemSci-300x105.png 300w\" sizes=\"auto, (max-width: 649px) 100vw, 649px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Enantioselective synthesis of configurationally stable [5]helicenes containing 1,2-azaborine units Catherine Olguin, Christian Tabacaru, Lennart Besse, Martin Simon, Christopher Golz, Marcos Humanes, Manuel A. Fern\u00e1ndez-Rodr\u00edguez, Patricia Garc\u00eda-Garc\u00eda,* Maike M\u00fccke, Ricardo A. Mata* and Manuel Alcarazos* Two different families of BN-doped [5]helicenes have been efficiently synthesized through a highly enantioselective, intramolecular, Au-catalyzed alkyne hydroarylation reaction. Key for &hellip; <a href=\"https:\/\/quibio.web.uah.es\/group\/chem-sci-2026\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Chem. Sci. 2026<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[],"class_list":["post-4307","post","type-post","status-publish","format-standard","hentry","category-noticias"],"_links":{"self":[{"href":"https:\/\/quibio.web.uah.es\/group\/wp-json\/wp\/v2\/posts\/4307","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/quibio.web.uah.es\/group\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/quibio.web.uah.es\/group\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/quibio.web.uah.es\/group\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/quibio.web.uah.es\/group\/wp-json\/wp\/v2\/comments?post=4307"}],"version-history":[{"count":2,"href":"https:\/\/quibio.web.uah.es\/group\/wp-json\/wp\/v2\/posts\/4307\/revisions"}],"predecessor-version":[{"id":4310,"href":"https:\/\/quibio.web.uah.es\/group\/wp-json\/wp\/v2\/posts\/4307\/revisions\/4310"}],"wp:attachment":[{"href":"https:\/\/quibio.web.uah.es\/group\/wp-json\/wp\/v2\/media?parent=4307"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/quibio.web.uah.es\/group\/wp-json\/wp\/v2\/categories?post=4307"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/quibio.web.uah.es\/group\/wp-json\/wp\/v2\/tags?post=4307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}