Synthesis and Photophysical Behavior of a Highly Fluorescent Family of Unsymmetrical Organoboron Complexes Containing 5-(Pyridin-2-ylmethylene)imidazolidine-2,4-dione Moieties

M. Soledad Garre, Raúl Losantos, Sara Gutiérrez, David Sucunza, Patricia García-García, Diego Sampedro and Juan J. Vaquero

J. Org. Chem., Article ASAP
DOI: 10.1021/acs.joc.9b02451

A new and highly fluorescent family of unsymmetrical organoboron complexes containing 5-(pyridin-2-ylmethylene)imidazolidine-2,4-dione moieties has been synthesized in three steps. These compounds show strong absorptions covering a wide range of the UV–vis spectrum and are strongly emissive (ϕf of up to 0.92 in CH3CN). Moreover, two fluorophores that include an alkyne or an azide group at the end of the alkyl chain and with potential utility in bioorthogonal chemistry have been developed. One of these, in which the glycol substituent provides an enhanced water solubility without compromising the fluorescence (ϕf = 0.85 in water), may be of particular importance.

Merry Christmas!

Dr. Abraham Mendoza talk

Dr. Abraham Mendoza, Stockholm University (Sweden)
Asymmetric synthesis with chiral carbon-atom precursors
Sala de Grados, Edificio de Farmacia, UAH. October 24th, 17.00.

AMendoza talk

UK-Spain Organometallic Chemistry Symposium (USOCS2019)

UK-Spain Organometallic Chemistry Symposium (USOCS2019),  Alcalá de Henares, September 17-19th:

· BN-Arenes: Synthesis, Reactivity and Properties
Alberto Abéngozar, Isabel Valencia, Miguel Ángel Fernández, Luis Manuel Frutos, Antonio Salgado, Adrián Pérez Redondo, Patricia García-García, David Sucunza, Juan J. Vaquero

· Decarbonylation Processes in k3 -(N^C^C) Gold (III) Carboxylates
Estíbaliz Merino, Hélène Beucher, Alexandre Genoux, Thomas Fox, Cristina Nevado

· Gold-catalyzed regiodivergent cyclization of alkynylcyclobutanes
M. Soledad Garre, David Sucunza, Estíbaliz Merino, Enrique Agular, Patricia García-García, Juan J. Vaquero

· Stereoselective synthesis of versatile trifluoromethyl substituted borocyclopropanes
Julia Altarejos, David Sucunza, Ana Caballero, Pedro J. Pérez, Juan J. Vaquero, Javier Carreras

EFMC-ASMC19 (International Symposium on Advances in Synthetic and Medicinal Chemistry) and ASMC-YSMC (6th EFMC Young Medicinal Chemist Symposium)

INTO THE ILK-αPARVIN INTERACTION AS A NEW STRATEGY AGAINST CHRONIC KIDNEY DISEASE
García Marín, Javier; De Frutos, Sergio; Griera, Mercedes; Alajarín Ferrandez, Ramón; Griera Merino, Mercedes; Vaquero López, Juan J.; Rodriguez Puyol, Diego; Rodriguez Puyol, Manuel

· International Symposium on Advances in Synthetic and Medicinal Chemistry, September 1-5th, Athens
· 6th EFMC Young Medicinal Chemist Symposium, September 5-6th, Athens

Almirall prize SEQT – Javier García Marín

Javier García Marín won Almirall prize of Sociedad Española de Química Terapéutica (SEQT) para Investigadores Noveles en el Campo de la Búsqueda y desarrollo de Nuevos Fármacos. Congratulations!

The award was received during the 19th Meeting of the Spanish Society of Medicinal Chemistry, Vitoria.
Flash communication:
New tools in medicinal chemistry: design, synthesis & evaluation of new molecules for the modulation of integrin linked kinase: a new target for chronic kidney disease.

Master’s Thesis “Drug Discovery” 2019

School of Drug Discovery of the Interuniversity Master’s Degree in Drug Discovery

In this edition, five works tutored in the group have been presented. Congratulations!

• Julia Altarejos “Síntesis estereoselectiva de trifluorometilciclopropilboronatos”
• Paula Flores “Síntesis de compuestos policíclicos mediante ciclaciones electrofílicas de eninos”
• Miriam Ramírez “Synthesis of small molecules as mimetics of the epitope segment in ILK-a-parvin protein-protein interaction”
• Alexey Sanduev “Design and synthesis of dicationic cromophores with application in bioimaging”
• Silvia Simón “Synthesis of modulators of integrin-linked kinase (ILK)”