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Palabras clave: Heterocycles; Cations; Chromophores; Synthesis; Nonlinear optics
Resumen
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Category Archives: 2010
Baeza et al. European Journal of Organic Chemistry. 2010;2010(29):5607 -5618. Title
Application of Selective Palladium-Mediated Functionalization of the Pyrido%@5B3′,2′:4,5%@5Dpyrrolo%@5B1,2-c%@5Dpyrimidine Heterocyclic System for the Total Synthesis of Variolin B and Deoxyvariolin B
Palabras clave: Cross-coupling; Total synthesis; Natural products; Heterocycles
Resumen
Abstract The reaction of protected 3-bromo-2-(bromomethyl)-4-methoxypyrrolo%@5B2,3-b%@5Dpyridine and tosylmethyl isocyanide (TosMIC) afforded a pyrido%@5B3?,2?:4,5%@5Dpyrrolo%@5B1,2-c%@5Dpyrimidine derivative in good yield. This compound was transformed through installation of the pyrimidine moiety in the C5 position, hydrolysis, and decarboxylation in an advanced intermediate for the total or formal synthesis of the naturalalkaloid variolin B. Reaction of 3-bromo-2-(bromomethyl)-4-chloropyrrolo%@5B2,3-b%@5Dpyridine with N-tosylmethyl dichloroformimide as a synthetic TosMIC equivalent afforded trihalo-substituted pyrido%@5B3?,2?:4,5%@5Dpyrrolo%@5B1,2-c%@5Dpyrimidine. This compound was used in a new total synthesis of the alkaloid variolin B by selective and sequential C?N, C?C, and C?O palladium-mediated functionalization at the C9, C5, and C4 positions of the pyrido%@5B3?,2?:4,5%@5Dpyrrolo%@5B1,2-c%@5Dpyrimidine system. A formal synthesis of deoxyvariolin B is also described by using the same synthetic strategy.
Deligeorgiev et al. Phosphorus, Sulfur, and Silicon and the Related Elements. 2010;185(11):2292 -2302. Title
Publications > Deligeorgiev et al
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Resumen
An improved green procedure for the synthesis of 2-aryl- and 2-hetarylbenzothiazoles by condensation of equivalent amounts of 2,2?-diaminodiphenyldisulfides or 2-aminothiophenols and various aromatic aldehydes in PEG 200/400 under microwave irradiation has been developed. This method allows the synthesis of 2-arylbenzothiazoles in high yields and with high purity regardless of the state of the starting compounds (liquid or solid) or the nature of the substituents in the aromatic ring.
Deligeorgiev et al. Coloration Technology. 2010;126(2):55 -80. Styryl dyes – synthesis and applications during the last 15 years
Publications > Deligeorgiev et al
Styryl dyes – synthesis and applications during the last 15 years
Resumen
One of the most widely used and important groups of functional dyes are the styryl dyes and a review of this functional dye class has not been published for more than 15?years. In this review article, we describe the new trends in the synthesis of a range of novel intermediates and styryl dyes and include the most interesting examples of their high-tech applications. However, this review is not intended to be comprehensive because of the large number of styryl dye studies that have been carried out in this time. Styryl cyanine dyes are widely used in optical recording media in laser discs, as flexible dyes, laser dyes, as optical sensitisers and in various other fields, for example dye-sensitised solar cells and dyes with non-linear optical properties. Additionally, the most important applications for these dyes are in bio-labelling and in medicinal analysis.
Deligeorgiev et al. Mini-Reviews in Organic Chemistry. 2010;7(1):44 -53. Green chemistry in organic synthesis.
Publications > Deligeorgiev et al
Green chemistry in organic synthesis.
1. University of Sofia, Faculty of Chemistry, 1164 Sofia, Bulgaria. 2. University of Alcalá, Faculty of Pharmacy, 28871 Alcalá de Henares, Madrid, Spain.
Resumen
The development of the concepts for "Green Chemistry" and the main principles of this field are reviewed. Examples of the application of these principles in different areas of chemistry are included. The frequently used alternative solvents (green solvents - water, PEG, perfluorinated solvents, supercritical liquids) in preparative organic chemistry are described. The present and the future developments of green chemistry in education and organic chemical technology are considered. © 2010 Bentham Science Publishers Ltd.
Deligeorgiev et al. Coloration Technology. 2010;126(1):24 -30. Title
Deligeorgiev et al. Journal. 2010;17(5):783 -788. Title
Publications > Deligeorgiev et al
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Palabras clave: Selective S-alkylation; Mercaptoazoles; Ultrasound irradiation
Resumen
A series of 2-alkylthio derivatives of hetaryl thiols were synthesized by selective S-alkylation with alkyl halides (bromides and iodides) with ultrasonic irradiation at room temperature. The reaction was found to be generally applicable to hetaryl thiol derivatives with different substituents in the aromatic nucleus and various alkyl halides. The reaction gives high to excellent yields of products with high purity.