Merry Christmas!

Dr. Abraham Mendoza talk

Dr. Abraham Mendoza, Stockholm University (Sweden)
Asymmetric synthesis with chiral carbon-atom precursors
Sala de Grados, Edificio de Farmacia, UAH. October 24th, 17.00.

AMendoza talk

UK-Spain Organometallic Chemistry Symposium (USOCS2019)

UK-Spain Organometallic Chemistry Symposium (USOCS2019),  Alcalá de Henares, September 17-19th:

· BN-Arenes: Synthesis, Reactivity and Properties
Alberto Abéngozar, Isabel Valencia, Miguel Ángel Fernández, Luis Manuel Frutos, Antonio Salgado, Adrián Pérez Redondo, Patricia García-García, David Sucunza, Juan J. Vaquero

· Decarbonylation Processes in k3 -(N^C^C) Gold (III) Carboxylates
Estíbaliz Merino, Hélène Beucher, Alexandre Genoux, Thomas Fox, Cristina Nevado

· Gold-catalyzed regiodivergent cyclization of alkynylcyclobutanes
M. Soledad Garre, David Sucunza, Estíbaliz Merino, Enrique Agular, Patricia García-García, Juan J. Vaquero

· Stereoselective synthesis of versatile trifluoromethyl substituted borocyclopropanes
Julia Altarejos, David Sucunza, Ana Caballero, Pedro J. Pérez, Juan J. Vaquero, Javier Carreras

EFMC-ASMC19 (International Symposium on Advances in Synthetic and Medicinal Chemistry) and ASMC-YSMC (6th EFMC Young Medicinal Chemist Symposium)

INTO THE ILK-αPARVIN INTERACTION AS A NEW STRATEGY AGAINST CHRONIC KIDNEY DISEASE
García Marín, Javier; De Frutos, Sergio; Griera, Mercedes; Alajarín Ferrandez, Ramón; Griera Merino, Mercedes; Vaquero López, Juan J.; Rodriguez Puyol, Diego; Rodriguez Puyol, Manuel

· International Symposium on Advances in Synthetic and Medicinal Chemistry, September 1-5th, Athens
· 6th EFMC Young Medicinal Chemist Symposium, September 5-6th, Athens

Almirall prize SEQT – Javier García Marín

Javier García Marín won Almirall prize of Sociedad Española de Química Terapéutica (SEQT) para Investigadores Noveles en el Campo de la Búsqueda y desarrollo de Nuevos Fármacos. Congratulations!

The award was received during the 19th Meeting of the Spanish Society of Medicinal Chemistry, Vitoria.
Flash communication:
New tools in medicinal chemistry: design, synthesis & evaluation of new molecules for the modulation of integrin linked kinase: a new target for chronic kidney disease.

Master’s Thesis “Drug Discovery” 2019

School of Drug Discovery of the Interuniversity Master’s Degree in Drug Discovery

In this edition, five works tutored in the group have been presented. Congratulations!

• Julia Altarejos “Síntesis estereoselectiva de trifluorometilciclopropilboronatos”
• Paula Flores “Síntesis de compuestos policíclicos mediante ciclaciones electrofílicas de eninos”
• Miriam Ramírez “Synthesis of small molecules as mimetics of the epitope segment in ILK-a-parvin protein-protein interaction”
• Alexey Sanduev “Design and synthesis of dicationic cromophores with application in bioimaging”
• Silvia Simón “Synthesis of modulators of integrin-linked kinase (ILK)”

6th Symposium of Medicinal Chemistry Young Researchers

SYNTHESIS OF MODULATORS OF INTEGRIN-LINKED KINASE (ILK)
S. Simón de la Fuente, F. Maqueda, J. García-Marín, J.L. Aceña and J.J. Vaquero

SYNTHESIS OF SMALL MOLECULES AS MIMETICS OF THE EPITOPE SEGMENT IN ILK-α-PARVIN PROTEIN-PROTEIN INTERACTION
M. Ramírez Rozalén, J. García Marín, R. Alajarín and J. J. Vaquero

NEW SYNTHETIC STRATEGIES FOR TREATMENT OF THE RENAL DISEASE: SYNTHESIS OF PEPTIDE NUCLEIC ACIDS
F. Maqueda-Zelaya, V. Miguel, J. L. Aceña, S. Lamas and J. J. Vaquero

NOVEL HIGHLY FLUORESCENT FAMILY OF UNSYMMETRIC ORGANOBORON COMPLEXES WITH 5-(PYRIDIN-2-YLMETHYLENE)IMIDAZOLIDINE-2,4-DIONE SYSTEMS
M. S. Garre, R. Losantos, S. Gutiérrez, D. Sucunza, P. García-García, D. Sampedro and J. J. Vaquero

SYNTHESIS OF NOVEL β-TURN LIKE MIMETICS
A. González, N. Mateu, J. L. Aceña, S. Fustero and J. J. Vaquero

XXXVII Bienal RSEQ conference

Flash communications:

– Gold (I)-Catalyzed Cycloisomerization of 1,3,5-Trien-7-ynes: A Novel and General Approach to Phenanthrenes
Manuel A. Fernández-Rodríguez, Patricia García-García, Roberto Sanz, Juan J. Vaquero, Ana Milián-López

– Electrophilic Cyclizations of Alkynylcyclobutanes and -cyclopropanes
Patricia García-García, David Sucunza, Enrique Aguilar, Juan J. Vaquero, M. Soledad Garre

Poster:

– Azaborine synthesis by cascade borocyclization of o-alkynyl anilines
Ester Sans-Panadés, Manuel A. Fernández-Rodríguez, Patricia García-García, Juan J. Vaquero

Dr. Aleksey Vasilev talk

Dr. Aleksey Aleksandrov Vasilev, Sofia University (Bulgaria)
E-Z Photoisomerization Stimulated by Triplet-Triplet Annihilation Photon Energy Up-conversion Light 
Multipurpose Building, UAH. June 27th, 12.00.

Vasilev talk

A New Member of the BN-Phenanthrene Family: Understanding the Role of the B—N Bond Position

Alberto Abengózar, David Sucunza, Patricia García-García, Diego Sampedro, Adrián Pérez-Redondo, and Juan J. Vaquero

J. Org. Chem., Article ASAP
DOI: 10.1021/acs.joc.9b00800

3,4-Dihydro-4-aza-3-boraphenanthrene, which shows the highest fluorescence quantum yield of all nonsubstituted BN-phenanthrenes reported to date (ϕF = 0.61), has been synthesized in only three steps (76% overall yield) from easily accessible 1-bromo-2-vinylnaphthalene, along with several substituted derivatives. The reactivity of these previously unknown BN-aromatic compounds toward organolithium compounds and bromine has been studied. This latter reaction affords bromo-substituted compounds that are suitable for further functionalization via Suzuki and Sonogashira couplings, with complete regioselectivity. The optical properties and excited state deactivation mechanisms of selected compounds were studied using computational methods.