Miembros

Javier García

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Javier García Marín

Publons: R-6014-2016

  • 2023-Present: Assistant Professor, Universidad de Alcalá.
  • 2022-2023:’Margarita Salas’ Postdoctoral Research Fellow, University of Bath (United Kingdom) (Prof. Carmen Domene).
  • 2020-2022: Postdoc Sonsoles Martín Santamaría group, Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC). Thesis defense, 23.09.2020.
  • 2018: Predoctoral stay at University of Bristol, Center for Computational Chemistry, (United Kingdom) (Prof. Adrian. J. Mulholland).
  • 2017-2020 FPU grant MINECO.
  • 2016-2017: FPI grant Universidad de Alcalá.
  • 2015: Master Drug Discovery, Universidad Complutense de Madrid.
  • 2014: Graduated (Pharmacy) at the Universidad Complutense de Madrid.
  • 2013: CNIO Summer Training Program Fellow at Spanish National Cancer Research Center (CNIO) / Experimental Therapeutics Programme, Medicinal Chemistry Section (Dr. Joaquín Pastor / Sonia Martínez).

Publications in the group

Insight into the mechanism of molecular recognition between human Integrin-Linked Kinase and Cpd22 and its implication at atomic level.
Javier García-Marín, Diego Rodríguez-Puyol, Juan J Vaquero
J Comput Aided Mol Des. 2022 Aug;36(8):575-589. doi: 10.1007/s10822-022-00466-1.
Pyridazino-pyrrolo-quinoxalinium salts as highly potent and selective leishmanicidal agents targeting trypanothione reductase.
Héctor de Lucio, Javier García-Marín, Patricia Sánchez-Alonso, Juan Carlos García-Soriano, Miguel Ángel Toro, Juan J Vaquero, Federico Gago, Ramón Alajarín, Antonio Jiménez-Ruiz
Eur J Med Chem. 2022, 227, 113915
A Computer-Driven Scaffold-Hopping Approach Generating New PTP1B Inhibitors from the Pyrrolo%1,2-a%quinoxaline Core.
Javier García-Marín, Mercedes Griera, Ramón Alajarín, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Juan J Vaquero
ChemMedChem. 2021 Sep 16;16(18):2895-2906. doi: 10.1002/cmdc.202100338.
Pyrrolo%1,2-a%quinoxal-5-inium salts and 4,5-dihydropyrrolo%1,2-a%quinoxalines: Synthesis, activity and computational docking for protein tyrosine phosphatase 1B.
Patricia Sánchez-Alonso, Mercedes Griera, Javier García-Marín, Manuel Rodríguez-Puyol, Ramón Alajarín, Juan J Vaquero, Diego Rodríguez-Puyol
Bioorg Med Chem. 2021 Jul 3; 44:116295.
Tripeptides as Integrin-Linked Kinase Modulating Agents Based on a Protein-Protein Interaction with α-Parvin.
Javier Garcia-Marin, Mercedes Griera-Merino, Alejandra Matamoros-Recio, Sergio de Frutos, Manuel Rodríguez-Puyol, Ramón Alajarín, Juan J Vaquero, Diego Rodríguez-Puyol
ACS Med Chem Lett. 2021 Jul 15;12(11):1656-1662. doi: 10.1021/acsmedchemlett.1c00183.
Pyrrolo%@5B1,2-a%@5Dquinoxalines: Insulin Mimetics that Exhibit Potent and Selective Inhibition against Protein Tyrosine Phosphatase 1B.
Javier García-Marín, Mercedes Griera, Patricia Sánchez-Alonso, Bruno Di Geronimo, Francisco Mendicuti, Manuel Rodríguez-Puyol, Ramón Alajarín, Beatriz de Pascual-Teresa, Juan J Vaquero, Diego Rodríguez-Puyol
ChemMedChem 2020, 15, 1788