Archivo de la categoría: 2016

Sucunza et al. J Org Chem. 2016;81(21):10126-10135. Recent Advances in the Synthesis of Azonia Aromatic Heterocycles.

Publicaciones > Sucunza et al

Recent Advances in the Synthesis of Azonia Aromatic Heterocycles.

Department of Organic and Inorganic Chemistry, University of Alcala , 28871 Alcala de Henares, Madrid, Spain.

Abstract

Azonia aromatic heterocycles are an important subclass of aza-heterocyles as they are the structural motif of relevant cationic alkaloids, and they have a wide range of potential applications such as bioactive compounds and organic materials. In this Synopsis, recent and novel approaches to their synthesis are surveyed, with particular emphasis on ring-closing metathesis reactions and annulation reactions based on C-H activation.

Gutierrez et al. Org Lett. 2016;18(14):3378-81. Synthesis of 1-Substituted Isoquinolines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Cassiarin A.

Publicaciones > Gutierrez et al

Synthesis of 1-Substituted Isoquinolines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Cassiarin A.

Departamento de Quimica Organica y Quimica Inorganica, Universidad de Alcala , Alcala de Henares 28871, Spain.

Abstract

A new method for the synthesis of 1-substituted isoquinolines by a heterocyclization that involves alpha-benzyl TosMIC derivatives and different electrophiles has been developed. This methodology has been successfully applied to a total synthesis of cassiarin A, an alkaloid with potent antiplasmodial activity against Plasmodium falciparum.