Nuevo artículo, Eur. J. Org. Chem. 08.23

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Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides

Mercedes Zurro, Sergio Torres-Oya, Estíbaliz Merino*

Eur. J. Org. Chem. 2023, Accepted Articles
DOI: 10.1002/ejoc.202300535

Synthesis of anticancer drug bicalutamide promoted by visible light in one step from the corresponding N-arylacrylamide is described. This approach involves a one-pot hydroxysulfonylation reaction via a photocatalytic redox process. The use of Na2Eosin Y as photocatalyst and blue light allows the access to a broad range of α-hydroxysulfonylamides bearing a quaternary center in moderate to good yields with complete regioselectivity via radical process.