Otero et al. Tetrahedron Lett. 2015;56(1):195 -198.

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Gold-catalyzed synthesis of oxepinones: an experimental mechanistic evidence


The isolation of a bicyclic lactone and its room temperature isomerization in CDCl3 to the expected oxepinone allows confirmation of a previously proposed mechanism for the gold-catalyzed synthesis of oxepinones from donor–acceptor alkynylcyclopropanes. However, the unsuccessful conversion of another bicyclic lactone into its corresponding oxepinone points out to a substrate-dependent mechanism.