Visible-light-initiated metal-free Csp3–Csp3 to Csp3–N conversion in homobenzylic sulfonamides with N-iodoimides

Guillermo Morales-Ortega,   Estíbaliz Merino  and  Javier Carreras*

We report a simple protocol for the transformation of Csp3–Csp3 to Csp3–N in homobenzylic sulfonamides in combination with N-iodoimides to form gem-diamino derivatives. The reaction exhibits a wide functional group tolerance and allows the incorporation of bioactive-derived fragments. The mechanistic insights provided by control experiments and DFT calculations suggest that an imine intermediate is formed after C−C bond cleavage.

Chem. Sci. 2025
DOI: 10.1039/D5SC02168E