All posts by Javier García Marín

Angewandte Chemie 03.24

Asymmetric, Remote C(sp3)−H Arylation via Sulfinyl-Smiles Rearrangement

Yawen Hu, Cédric Hervieu,  Dr. Estíbaliz Merino*, Prof. Cristina Nevado*

Angew. Chem. Int. Ed. 2024, Early View
DOI: anie.202319158

An efficient asymmetric remote arylation of C(sp3)−H bonds under photoredox conditions is described here. The reaction features the addition radicals to a double bond followed by a site-selective radical translocation (1,n-hydrogen atom transfer) as well as a stereocontrolled aryl migration via sulfinyl-Smiles rearrangement furnishing a wide range of chiral α-arylated amides with up to >99 : 1 er. Mechanistic studies indicate that the sulfinamide group governs the stereochemistry of the product with the aryl migration being the rate determining step preceded by a kinetically favored 1,n-HAT process.

Renedo et al. Advanced Synthesis & Catalysis. 2024;366(9):2079 -2089. Gold-Catalyzed Tandem Oxidation-Migration of 3-Propargyl Indoles: Synthesis of α-Indol-3-yl α,β-Unsaturated Carbonyls.

Publications > Renedo et al

Gold-Catalyzed Tandem Oxidation-Migration of 3-Propargyl Indoles: Synthesis of α-Indol-3-yl α,β-Unsaturated Carbonyls.

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Org. Lett 02.24

Visible Light-Mediated Heterodifunctionalization of Alkynylazobenzenes for 2H-Indazole Synthesis

Clara Mañas and Estíbaliz Merino*

Org. Lett. 2024, ASAP
DOI: acs.orglett.4c00097

We disclose the heterodifunctionalization of alkynylazobenzenes promoted exclusively by visible light in the absence of any transition metal and/or photocatalyst. This reaction features excellent regioselectivity on a broad variety of substrates with perfect atom economy. Alcohols, carboxylic acids, thiols, amides, heterocycles, and even water are suitable substrates for the promotion of the oxyamination, sulfenoamination, and diamination reactions. In this manner, biologically active indazole scaffolds can be rapidly assembled from alkyne feedstocks.

Javier Recio

Javier Recio Ramos

Assistant Professor

  • 2024-Present: Assistant Professor at Universidad Rey Juan Carlos.
  • 2024: Postdoctoral researcher ‘Margarita Salas’, at Universidad de Alcalá (Prof.  Manuel Ángel Fernández).
  • 2022-2023: Postdoctoral researcher ‘Margarita Salas’ at CIB-CSIC (Spain) (Prof.  Ana Martínez).
  • 2021: Scientific Supervisor at Centro de Química Aplicada y Biotecnología (CQAB) UAH.
  • 2020-2021: Postdoctoral researcher (ERC-associated project), Universität Hamburg (Germany), (Prof. Axel Jacobi von Wangelin).
  • 2020 PhD in Medicinal Chemistry (FPI-UAH grant) at Universidad de Alcalá, (Prof. Julio Álvarez / Prof. Carolina Burgos).
  • 2018: Predoctoral research stay, Universität Hamburg (Germany) (Prof. Axel Jacobi von Wangelin).
  • 2015 Master in Química Fina by Universidad de Alcalá (Spain).
  • 2014: Graduted (Chemistry) at Universidad de Alcalá (Spain).

Carmen Callejón

Carmen Callejón Martínez

  • Project associate researcher Universidad de Alcalá (2022)
  • “Contrato Yo Investigo” researcher at Universidad de Alcalá (2021 2022)
  • Master Applied and Pharmacological Chemistry, Universidad de Castellón (2020/2021)
  • Graduated (Cehmistry) at the Universidad de Jaen (2019)