All posts by Javier García Marín

Miembros

Jaime Mateos

Jaime Mateos Gil

Assistant Professor

Publons: J-2816-2014
  • 2023-Present: Assistant Professor, Universidad de Alcalá.
  • 2021-2023: Juan de la Cierva-Incorporación” Researcher, CIQUS-Universidad de Santiago de Compostela.
  • 2020-2021: Postdoctoral researcher, Universidad de Granada (Prof. Juan M. Cuerva / Prof. Alba Millán).
  • 2018-2020: Postdoctoral researcher, Rijkuniversiteit Groningen (Holland) (Prof. Ben L. Feringa).
  • 2016-2018: Postdoctoral researcher, CIQUS-Universidad de Santiago de Compostela (Prof. Martín Fañanás).
  • 2015: PhD in Organic Chemistry at Universidad Complutense de Madrid (Prof. Nazario Martín / Prof. Mª Ángeles Herranz).
  • 2012: Predoctoral research stay, Kyoto University (Japan) (Prof. Yasujiro Murata).
  • 2012: Predoctoral research stay, TARA Center-University of Tsukuba (Japan) (Prof. Takeshi Akasaka).
  • 2010: Graduted (Chemistry) at Universidad Complutense de Madrid.
Noticias

Adv. Synth. Catal. 2023

Total Synthesis of Laetevirenol A via Regioselective Gold-Catalyzed and Acid-Promoted Cyclizations

Ana Milián, Lucía Sánchez-Jiménez, Jaime Tostado, Juan J. Vaquero, Manuel A. Fernández-Rodríguez*, Patricia García-García*

Adv. Synth. Catal. 2023, Accepted Articles
DOI: 10.1002/adsc.202301136

The total synthesis of Laetevirenol A, a natural product with antioxidant activity, has been achieved. A gold-catalyzed cycloisomerization of an o-alkenyl-o’-alkynylbiphenyl has been used as the key step for the construction of the phenanthrene moiety present in Laetevirenol A. Several studies in model substrates have been carried out to unveil the effect of substituents in different locations in the outcome of this cyclization, which allowed the design of an appropriate precursor for the fundamental gold-catalyzed cycloisomerization. The suitably functionalized phenanthrene intermediate obtained in this key step could be further transformed into Laetevirenol A via a Friedel-Crafts cyclization, which also turned out to be dependent on the nature of the substituents. Finally, Laetevirenol A was obtained in 10 steps from commercially available substrates, with a 20% global yield.