Visible Light-Mediated Heterodifunctionalization of Alkynylazobenzenes for 2H-Indazole Synthesis
Clara Mañas and Estíbaliz Merino*
Org. Lett. 2024, ASAP
DOI: acs.orglett.4c00097
We disclose the heterodifunctionalization of alkynylazobenzenes promoted exclusively by visible light in the absence of any transition metal and/or photocatalyst. This reaction features excellent regioselectivity on a broad variety of substrates with perfect atom economy. Alcohols, carboxylic acids, thiols, amides, heterocycles, and even water are suitable substrates for the promotion of the oxyamination, sulfenoamination, and diamination reactions. In this manner, biologically active indazole scaffolds can be rapidly assembled from alkyne feedstocks.
Javier Recio Ramos
Assistant Professor
2024-Present: Assistant Professor at Universidad Rey Juan Carlos.
2024: Postdoctoral researcher ‘Margarita Salas’, at Universidad de Alcalá (Prof. Manuel Ángel Fernández).
2022-2023: Postdoctoral researcher ‘Margarita Salas’ at CIB-CSIC (Spain) (Prof. Ana Martínez).
2021: Scientific Supervisor at Centro de Química Aplicada y Biotecnología (CQAB) UAH.
2020-2021: Postdoctoral researcher (ERC-associated project), Universität Hamburg (Germany), (Prof. Axel Jacobi von Wangelin).
2020 PhD in Medicinal Chemistry (FPI-UAH grant) at Universidad de Alcalá, (Prof. Julio Álvarez / Prof. Carolina Burgos).
2018: Predoctoral research stay, Universität Hamburg (Germany) (Prof. Axel Jacobi von Wangelin).
2015 Master in Química Fina by Universidad de Alcalá (Spain).
2014: Graduted (Chemistry) at Universidad de Alcalá (Spain).
FPI (project-associated), Universidad de Alcalá (2022-2023)
Master Organic Chemsitry , Universidad Autónoma de Madrid (2022-2023)
Graduated (Chemistry), Universidad Autónoma de Madrid (2018-2022)
Publications in the group
Elio Mollá Arroyo
FPI (project-associated), Universidad de Alcalá (2022-2023)
Master Organic Chemsitry , Universidad Autónoma de Madrid (2022-2023)
Graduated (Chemistry), Universidad Autónoma de Madrid (2017-2022)
Carmen Callejón Martínez
Project associate researcher Universidad de Alcalá (2022)
“Contrato Yo Investigo” researcher at Universidad de Alcalá (2021 2022)
Master Applied and Pharmacological Chemistry , Universidad de Castellón (2020/2021)
Graduated (Cehmistry) at the Universidad de Jaen (2019)
Guillermo Morales
Comunidad de Madrid Predoctoral Gran (2023)
Project associate researcher FIBioHRC Universidad de Alcalá (2022-2023)
Master Drug Discovery , Universidad Complutense (2021-2022)
Graduated (Pharmacy) at the Universidad de Alcalá (2017-2022)
Sergio Torres
orcid.org/0000-0002-1003-519X
Project associate researcher FIBioHRC Universidad de Alcalá (2022-2023)
“Contrato Yo Investigo” researcher at Universidad de Alcalá (2021 2022)
Master Drug Discovery , Universidad Complutense (2021/2022)
Master in Industrial Chemistry and Introduction to the Chemical Research, Universidad Autónoma de Barcelona (2017-2018)
Graduated in Chemistry at the Universidad Autónoma de Barcelona (2013-2017)
Publications in the group
Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides.
Mercedes Zurro, Sergio Torres-Oya, Estíbaliz Merino
Visible-Light-Mediated Regioselective Chlorosulfonylation of Acrylamides.
Mercedes Zurro, Sergio Torres-Oya, Guillermo G. Otárola, Juan José Vaquero, Estíbaliz Merino
Jose Antonio García García
Project associate researcher Universidad de Alcalá (2023)
Master Drug Discovery , Universidad de Alcalá (2021/2022)
Graduated at the Universidad de Extremadura (2021)
Marta Durán
Project associate researcher INNOREN-CM (P2022/BMD-7221 ) Universidad de Alcalá (2023)
Master Organic Chemistry , Universidad de Valencia (2022/2023)
Graduated at the Universidad Autónoma de Madrid (2021)
On January 11st, Francisco Maqueda successfully defended his doctoral thesis under the supervision of Prof. Juan José Vaquero and Dr. José Luis Aceña.
Thanks to all members of thesis tribunal: Dr. David Sucunza, Prof. Isabel Rozas and, Dr María Ángeles Castro
Congratulations to Dr. Maqueda!
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