All posts by Javier García Marín

Renedo et al. Advanced Synthesis & Catalysis. 2024;366(9):2079 -2089. Gold-Catalyzed Tandem Oxidation-Migration of 3-Propargyl Indoles: Synthesis of α-Indol-3-yl α,β-Unsaturated Carbonyls.

Publications > Renedo et al

Gold-Catalyzed Tandem Oxidation-Migration of 3-Propargyl Indoles: Synthesis of α-Indol-3-yl α,β-Unsaturated Carbonyls.

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Org. Lett 02.24

Visible Light-Mediated Heterodifunctionalization of Alkynylazobenzenes for 2H-Indazole Synthesis

Clara Mañas and Estíbaliz Merino*

Org. Lett. 2024, ASAP
DOI: acs.orglett.4c00097

We disclose the heterodifunctionalization of alkynylazobenzenes promoted exclusively by visible light in the absence of any transition metal and/or photocatalyst. This reaction features excellent regioselectivity on a broad variety of substrates with perfect atom economy. Alcohols, carboxylic acids, thiols, amides, heterocycles, and even water are suitable substrates for the promotion of the oxyamination, sulfenoamination, and diamination reactions. In this manner, biologically active indazole scaffolds can be rapidly assembled from alkyne feedstocks.

Javier Recio

Javier Recio Ramos

Assistant Professor

  • 2024-Present: Assistant Professor at Universidad Rey Juan Carlos.
  • 2024: Postdoctoral researcher ‘Margarita Salas’, at Universidad de Alcalá (Prof.  Manuel Ángel Fernández).
  • 2022-2023: Postdoctoral researcher ‘Margarita Salas’ at CIB-CSIC (Spain) (Prof.  Ana Martínez).
  • 2021: Scientific Supervisor at Centro de Química Aplicada y Biotecnología (CQAB) UAH.
  • 2020-2021: Postdoctoral researcher (ERC-associated project), Universität Hamburg (Germany), (Prof. Axel Jacobi von Wangelin).
  • 2020 PhD in Medicinal Chemistry (FPI-UAH grant) at Universidad de Alcalá, (Prof. Julio Álvarez / Prof. Carolina Burgos).
  • 2018: Predoctoral research stay, Universität Hamburg (Germany) (Prof. Axel Jacobi von Wangelin).
  • 2015 Master in Química Fina by Universidad de Alcalá (Spain).
  • 2014: Graduted (Chemistry) at Universidad de Alcalá (Spain).

Ángela Belén Ibarra

  • FPI (project-associated), Universidad de Alcalá (2022-2023)
  • Master Organic Chemsitry, Universidad Autónoma de Madrid (2022-2023)
  • Graduated (Chemistry), Universidad Autónoma de Madrid (2018-2022)

Publications in the group

Shaping cycles with light: a regiodivergent approach to tetracyclic aza-aromatic compounds.
Org. Chem. Front., 2024,11, 6974

Carmen Callejón

Carmen Callejón Martínez

  • Project associate researcher Universidad de Alcalá (2022)
  • “Contrato Yo Investigo” researcher at Universidad de Alcalá (2021 2022)
  • Master Applied and Pharmacological Chemistry, Universidad de Castellón (2020/2021)
  • Graduated (Cehmistry) at the Universidad de Jaen (2019)

Guillermo Morales

Guillermo Morales

  • Comunidad de Madrid Predoctoral Gran (2023)
  • Project associate researcher FIBioHRC Universidad de Alcalá (2022-2023)
  • Master Drug Discovery, Universidad Complutense (2021-2022)
  • Graduated (Pharmacy) at the Universidad de Alcalá (2017-2022)

Publications in the group

Visible-light-initiated metal-free C(sp(3)) -C(sp(3)) to C(sp(3)) -N conversion in homobenzylic sulfonamides with N-iodoimides.
Chem Sci. 2025, 16, 11413-11418. doi: 10.1039/d5sc02168e.

Sergio Torres

Sergio Torres

ORCID iD iconorcid.org/0000-0002-1003-519X

  • Project associate researcher FIBioHRC Universidad de Alcalá (2022-2023)
  • “Contrato Yo Investigo” researcher at Universidad de Alcalá (2021 2022)
  • Master Drug Discovery, Universidad Complutense (2021/2022)
  • Master in Industrial Chemistry and Introduction to the Chemical Research, Universidad Autónoma de Barcelona (2017-2018)
  • Graduated in Chemistry at the Universidad Autónoma de Barcelona (2013-2017)

Publications in the group

Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides.
Eur. J. Chem. 2023, e202300535.
Visible-Light-Mediated Regioselective Chlorosulfonylation of Acrylamides.
Synthesis 2023, 55, 1783