Our PhD candiate, Marta Durán, has participated in the the first edition of MEDCHEMXCHANGE, a new webinar series launched by the Sociedad Española de Química Terapéutica (SEQT) Early Career Scientists (SEQT-ECS) group.
Marta Durán – Webinar at EFMC
Category Archives: 2024
Martínez-Laguna et al. J Am Chem Soc. 2024;146(49):34014-34022. Alkanes C(1)-C(6) C-H Bond Activation via a Barrierless Potential Energy Path: Trifluoromethyl Carbenes Enhance Primary C-H Bond Functionalization.
Publications > Martínez-Laguna et al
Alkanes C(1)-C(6) C-H Bond Activation via a Barrierless Potential Energy Path: Trifluoromethyl Carbenes Enhance Primary C-H Bond Functionalization.
1. Departamento de Química and Laboratorio de Catálisis Homogénea, Unidad Asociada al CSIC, CIQSO-Centro de Investigación en Química Sostenible, Universidad de Huelva, Huelva 21007, Spain. 2. Departamento de Química Orgánica y Química Inorgánica, Instituto de Investigación Química "Andrés M. del Río" (IQAR), Universidad de Alcalá, Alcalá de Henares, Madrid 28805, Spain. 3. The Barcelona Institute of Science and Technology, Institute of Chemical Research of Catalonia (ICIQ-CERCA), Avgda. Països Catalans, 16, Tarragona 43007, Spain. 4. Departament de Química, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
Abstract
In this mixed computational and experimental study, we report a catalytic system for alkane C(1)-C(6) functionalization in which the responsible step for C-H bond activation shows no barrier in the potential energy path. DFT modeling of three silver-based catalysts and four diazo compounds led to the conclusion that the Tp(F)Ag═C(H)CF(3) (Tp(F) = fluorinated trispyrazolylborate ligand) carbene intermediates interact with methane without a barrier in the potential energy surface, a prediction validated by experimentation using N(2)═C(H)CF(3) as the carbene source. The array of alkanes from propane to n-hexane led to the preferential functionalization of the primary sites with unprecedented values of selectivity for an acceptor diazo compound. The lack of those barriers implies that selectivity can no longer be controlled by differences in the energy barriers. Molecular dynamics calculations (with propane as the model alkane) are consistent with the preferential functionalization of the primary sites due to a higher concentration of such C-H bonds in the vicinity of the carbenic carbon atom.
Mañas et al. J Org Chem. 2024;89(22):16883-16888. Copper-Catalyzed Hydroamination of 2-Alkynylazobenzenes: Synthesis of 3-Alkenyl-2H-Indazoles.
Copper-Catalyzed Hydroamination of 2-Alkynylazobenzenes: Synthesis of 3-Alkenyl-2H-Indazoles.
1. Departamento de Química Orgánica y Química Inorgánica, Instituto de Investigación Andrés M. del Río (IQAR), Facultad de Farmacia, Universidad de Alcalá, Alcalá de Henares, 28805 Madrid, Spain. 2. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Ctra. De Colmenar Viejo, Km. 9.100, 28034 Madrid, Spain.
Abstract
A copper-catalyzed intramolecular synthesis of 3-alkenyl-2H-indazoles from 2-alkynylazobenzenes is described. The reaction proceeds in a single step via C-N bond formation and a subsequent 1,2-hydride shift, affording products in high yields. DFT calculations suggest the 1,2-hydride shift as the rate-determining step. Further derivatization enables functionalization of the 3-alkenyl-2H-indazoles.
Mañas et al Org. Chem. Front. 2024 ;11(24):6974 -6988. Shaping cycles with light: a regiodivergent approach to tetracyclic aza-aromatic compounds.
Shaping cycles with light: a regiodivergent approach to tetracyclic aza-aromatic compounds.
Resumen
No hay resumen
Lerma-Berlanga et al. ChemCatChem. 2024;16(23):e202400909. Au Clusters Catalyze The Disulfide Metathesis Reaction By A Reductive Addition-Oxidative Elimination Mechanism.
Publications > Lerma-Berlanga et al
Au Clusters Catalyze The Disulfide Metathesis Reaction By A Reductive Addition-Oxidative Elimination Mechanism.
Palabras clave: Oxidative addition-reductive elimination (OARE) mechanism; Disulfide metathesis; Au cluster; Computational studies; Reusable catalyst
Resumen
No hay resumen
Humanes et al. Org Lett. 2024;26(31):6568-6573. Selective Synthesis of Boron-Functionalized Indenes and Benzofulvenes by BCl(3)-Promoted Cyclizations of ortho-Alkynylstyrenes.
Selective Synthesis of Boron-Functionalized Indenes and Benzofulvenes by BCl(3)-Promoted Cyclizations of ortho-Alkynylstyrenes.
1. Departamento de Química Orgánica y Química Inorgánica, Instituto de Investigación Química "Andrés M. del Río" (IQAR), Universidad de Alcalá (IRYCIS), 28805 Alcalá de Henares, Madrid, Spain. 2. Área de Química Orgánica, Departamento de Química, Facultad de Ciencias, Universidad de Burgos, Pza. Misael Bañuelos s/n, 09001 Burgos, Spain.
Abstract
A selective, metal-free synthesis of boron-functionalized indenes and benzofulvenes via BCl(3)-mediated cyclization of o-alkynylstyrenes is described. The method allows precise control over product formation by adjusting reaction conditions. These borylated products were utilized in diverse C-B bond derivatizations and in the total synthesis of Sulindac, a nonsteroidal anti-inflammatory drug, demonstrating the versatility and practicality of the developed methodology for synthetic applications.
Tostado et al. Org Lett. 2024;26(16):3343-3348. Synthesis of Seven- and Eight-Membered Rings by a Brønsted Acid Catalyzed Cationic Carbocyclization of Biphenyl Embedded Enynes.
Synthesis of Seven- and Eight-Membered Rings by a Brønsted Acid Catalyzed Cationic Carbocyclization of Biphenyl Embedded Enynes.
Universidad de Alcalá (IRYCIS). Departamento de Química Orgánica y Química Inorgánica, Instituto de Investigación Química "Andrés M. del Río" (IQAR), Autovía A-II, Km 33.1, 28805-Alcalá de Henares, Madrid, Spain.
Abstract
A Brønsted acid catalyzed cyclization of o-alkenyl-o'-alkynylbiaryls for the synthesis of biologically relevant dibenzo-fused medium-sized rings has been developed. The outcome of the cyclization is determined by the nature of the substituent at the alkyne, with arenes favoring seven-membered rings and alkyl substituents producing eight-membered rings. These reactions proceed via a vinyl cation, which is captured by water and, notably, by C-nucleophiles, such as electron-rich (hetero)arenes.
Hu et al. Angew Chem Int Ed Engl. 2024;:e202319158. Asymmetric, Remote C(sp(3) )-H Arylation via Sulfinyl-Smiles Rearrangement.
Asymmetric, Remote C(sp(3) )-H Arylation via Sulfinyl-Smiles Rearrangement.
1. Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland. 2. Departamento de Química Orgánica y Química Inorgánica Instituto de Investigación Química "Andrés M. del Río" (IQAR). Facultad de Farmacia, Universidad de Alcalá Alcalá de Henares, 28805, Madrid, Spain. 3. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Ctra. de Colmenar Viejo, Km. 9.100, 28034, Madrid, Spain.
Keywords: Asymmetric Remote Arylation; Hydrogen Atom Transfer; Photoredox Catalysis; Sulfinyl-Smiles Rearrangement; α-Arylated Amides
Abstract
An efficient asymmetric remote arylation of C(sp(3) )-H bonds under photoredox conditions is described here. The reaction features the addition radicals to a double bond followed by a site-selective radical translocation (1,n-hydrogen atom transfer) as well as a stereocontrolled aryl migration via sulfinyl-Smiles rearrangement furnishing a wide range of chiral α-arylated amides with up to >99 : 1 er. Mechanistic studies indicate that the sulfinamide group governs the stereochemistry of the product with the aryl migration being the rate determining step preceded by a kinetically favored 1,n-HAT process.
Renedo et al. Advanced Synthesis & Catalysis. 2024;366(9):2079 -2089. Gold-Catalyzed Tandem Oxidation-Migration of 3-Propargyl Indoles: Synthesis of α-Indol-3-yl α,β-Unsaturated Carbonyls.
Gold-Catalyzed Tandem Oxidation-Migration of 3-Propargyl Indoles: Synthesis of α-Indol-3-yl α,β-Unsaturated Carbonyls.
Palabras clave: carbonyls; gold; homogeneous catalysis; indoles; oxidation
Resumen
No hay resumen
Mañas and. Org Lett. 2024;26(9):1868-1873. Visible Light-Mediated Heterodifunctionalization of Alkynylazobenzenes for 2H-Indazole Synthesis.
Visible Light-Mediated Heterodifunctionalization of Alkynylazobenzenes for 2H-Indazole Synthesis.
1. Universidad de Alcalá, Departamento de Química Orgánica y Química Inorgánica, Instituto de Investigación Andrés del Río (IQAR), Facultad de Farmacia, 28805 Alcalá de Henares, Madrid, Spain. 2. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Ctra. de Colmenar Viejo, Km. 9.100, 28034 Madrid, Spain.
Abstract
We disclose the heterodifunctionalization of alkynylazobenzenes promoted exclusively by visible light in the absence of any transition metal and/or photocatalyst. This reaction features excellent regioselectivity on a broad variety of substrates with perfect atom economy. Alcohols, carboxylic acids, thiols, amides, heterocycles, and even water are suitable substrates for the promotion of the oxyamination, sulfenoamination, and diamination reactions. In this manner, biologically active indazole scaffolds can be rapidly assembled from alkyne feedstocks.
This inaugural session was organized in collaboration with the EFMC Young Scientists Network (YSN) as part of their #LunchandLearn initiative.