Dr. Teresa de Haro talk
Principal Scientist, Medicinal Chemistry, UCB
NCE Drug Discovery at UCB – Case Study: Inhibition of Plasmepsin X: A Promising Strategy Against Malaria
Friday 20th june, 12.15 h, Sala de grados, Faculty of Pharmacy
Category Archives: Noticias
Dr. Francisco Tato Moreno talk
Dr. Francisco Tato Moreno
Project Manager at Synthelia Organics
El papel de las CRO en la industria farmacéutica
Dr. Ana Belen Cuenca talk
Dr. Ana Belen Cuenca talk
Dr. Ana Belen Cuenca, Full Professor, Organic & Pharmaceutical Chemistry Department (Universitat Ramon Llul).
New reactions and structures involving main group elements
Sala de Grados, School of Pharmacy, UAH. May 23rd, 12.30.
Dr. Carlos Vila Descals talk
Dr. Carlos Vila Descals talk
Dr. Carlos Vila Descals, Associate professor, Organic Chemistry Department (Universidad de Valencia).
Stereoselective functionalization of nitrogen heterocycles using metal catalysis, organocatalysis or photocatalysis
Sala de Grados, School of Pharmacy, UAH. May 23rd, 12.30.
Chem. Sci. 2025
Visible-light-initiated metal-free Csp3–Csp3 to Csp3–N conversion in homobenzylic sulfonamides with N-iodoimides
Guillermo Morales-Ortega, Estíbaliz Merino and Javier Carreras*
We report a simple protocol for the transformation of Csp3–Csp3 to Csp3–N in homobenzylic sulfonamides in combination with N-iodoimides to form gem-diamino derivatives. The reaction exhibits a wide functional group tolerance and allows the incorporation of bioactive-derived fragments. The mechanistic insights provided by control experiments and DFT calculations suggest that an imine intermediate is formed after C−C bond cleavage.
Chem. Sci. 2025
DOI: 10.1039/D5SC02168E
Adv. Synth. Cat. 2025
Synthesis of Polysubstituted Naphthalenes via Metal-Free Borylative Cyclization of o-Alkynylstyrenes
Marcos Humanes, Manuel A. Fernández-Rodríguez,* Patricia García-García*
A selective, metal-free method for the synthesis of boron-functionalized polysubstituted naphthalenes via BCl3-mediated cyclization of α-substituted o-alkynylstyrenes is described. The reaction exhibits broad substrate scope, tolerating various groups such as ethers, sulfides and halogens, and delivers high yields under mild conditions, even at gram scale. The resulting Bpin-functionalized naphthalenes serve as versatile building blocks, facilitating further transformations of the C−B bond into C−H, C−C, C−I, C−O, and C−N bonds, thereby increasing molecular complexity and enabling the design of more functionalized products. Notably, this sustainable and straightforward protocol selectively introduces the Bpin group at the sterically hindered α-carbon of the naphthalene framework, complementing C–H borylations of the naphthalene core, that preferentially occur at the β-position. As a result, the developed approach significantly broadens the accessibility of B-functionalized naphthalene derivatives for synthetic and application-oriented purposes.
Adv. Synth. Cat. 2025
DOI: 10.1002/adsc.202500244
Dr. Francisco Juliá-Hernández Talk
Dr. Francisco Juliá-Hernández talk
Dr. Francisco Juliá-Hernández, Ramon y Cajal Fellow, Inorganic Chemistry Department (Universidad de Murcia).
Illuminating Earth-abundant Metals: New Opportunities in Organic Synthesis
Sala de Grados, School of Pharmacy, UAH. April 25th, 12.30.
Guillermo and Erica awarded with a Predoctoral Grant
Our two young members Guillermo Sánchez Mateos and Erica Salivioli have been awarded with a FPI-UAH contract to carry out their doctoral thesis at the UAH.
Congratulations 😊!
Patent 2025
Ligandos moduladores de la quinasa ligada a integrinas y uso de los mismos para el tratamiento de enfermedades
Marta Durán, Juan José Vaquero, Mercedes Griera, Sergio de Frutos, Diego Rodríguez Puyol, Javier García Marín*
La presente invención se refiere a nuevos compuestos que actúan como ligandos de la quinasa ligada a integrinas (del inglés ILK), facilitando la polimerización del citoesqueleto de actina y favoreciendo así el tráfico de receptores celulares desde los compartimentos intracelulares a la superficie de las células. Por este motivo, pueden ser utilizados en enfermedades como la diabetes mellitus tipo 2 o la diabetes insípida nefrogénica y, por extensión, en cualquier enfermedad en la que las alteraciones fisiopatológicas sean debidas, total o parcialmente, a un transporte transmembrana disminuido como las tubulopatías renales originadas por una pérdida de transportadores.
No: P202530222 (14/03/2025)
Adv. Synth. Cat. 2025
Combined Gold and Photoredox Catalysis: Synthesis of 3-Alkenyl-2H-Indazoles from 2-Alkynylazobenzenes
Clara Mañas, Estíbaliz Merino*
We disclose the intramolecular synthesis of 3-alkenyl-2H-indazoles from 2-alkynylazobenzenes, promoted by a dual catalysis using AuCl3 and a ruthenium photocatalyst under visible light irradiation. This reaction proceeds through hydroamination of the alkynyl fragment. The yields are influenced by electronic factors. Control experiments suggest that both radical and polar mechanisms operate in parallel. This transformation involves C−N bond formation and a 1,2-hydride shift. Additionally, derivatization was performed to demonstrate the versatility of this methodology..
Adv. Synth. Cat. 2025
DOI: 10.1002/adsc.202400990