On April 4th, Clara Mañas successfully defended her doctoral thesis under the supervision of Dr. Estíbaliz Merino: “Design and study of novel reactivities of alkynylazobenzenes”
Thanks to all members of thesis tribunal: Dr. Teresa Quirós, Dr. Eva Maya and Dr. María Ribagorda
Congratulations to Dr. Mañas!
Yawen Hu, Cédric Hervieu, Dr. Estíbaliz Merino*, Prof. Cristina Nevado*
Angew. Chem. Int. Ed. 2024, Early View
DOI: anie.202319158
| An efficient asymmetric remote arylation of C(sp3)−H bonds under photoredox conditions is described here. The reaction features the addition radicals to a double bond followed by a site-selective radical translocation (1,n-hydrogen atom transfer) as well as a stereocontrolled aryl migration via sulfinyl-Smiles rearrangement furnishing a wide range of chiral α-arylated amides with up to >99 : 1 er. Mechanistic studies indicate that the sulfinamide group governs the stereochemistry of the product with the aryl migration being the rate determining step preceded by a kinetically favored 1,n-HAT process. |
Last friday, March 16th, Dr. García García was appointed as Full Professor at the UAH.
Congratulations Patricia!
Last friday, March 1st, Dr. Estibaliz Merino successfully passed her exam and was appointed as Associate Professor at the UAH.
Congratulations Estíbaliz!
Torino, Italy, 25 – 27 February 2024
· Heterodifunctionalization of Alkynes Promoted Exclusively by Visible Light
Clara Mañas, Estíbaliz Merino
Flash communication
Clara Mañas and Estíbaliz Merino*
Org. Lett. 2024, ASAP
DOI: acs.orglett.4c00097
| We disclose the heterodifunctionalization of alkynylazobenzenes promoted exclusively by visible light in the absence of any transition metal and/or photocatalyst. This reaction features excellent regioselectivity on a broad variety of substrates with perfect atom economy. Alcohols, carboxylic acids, thiols, amides, heterocycles, and even water are suitable substrates for the promotion of the oxyamination, sulfenoamination, and diamination reactions. In this manner, biologically active indazole scaffolds can be rapidly assembled from alkyne feedstocks. |
On January 11st, Francisco Maqueda successfully defended his doctoral thesis under the supervision of Prof. Juan José Vaquero and Dr. José Luis Aceña.
Thanks to all members of thesis tribunal: Dr. David Sucunza, Prof. Isabel Rozas and, Dr María Ángeles Castro
Congratulations to Dr. Maqueda!
Cédric Hervieu, Mariia S. Kirillova, Yawen Hu, Sergio Cuesta-Galisteo, Estíbaliz Merino*, Cristina Nevado
Nat. Chem. 2024, Accepted Articles
DOI: 10.1038/s41557-023-01414-8
| Two- or one-electron-mediated difunctionalizations of internal alkenes represent straightforward approaches to assemble molecular complexity by the simultaneous formation of two contiguous Csp3 stereocentres. Although racemic versions have been extensively explored, asymmetric variants, especially those involving open-shell C-centred radical species, are much more limited both in number and scope. Here we describe enantioenriched arylsulfinylamides as all-in-one reagents for the efficient asymmetric, intermolecular aminoarylation of alkenes. Under mild photoredox conditions, nitrogen addition of the arylsulfinylamide onto the double bond, followed by 1,4-translocation of the aromatic ring, produce, in a single operation, the corresponding aminoarylation adducts in enantiomerically enriched form. The sulfinyl group acts here as a traceless chiral auxiliary, as it is eliminated in situ under the mild reaction conditions. Optically pure β,β-diarylethylamines, aryl-α,β-ethylenediamines and α-aryl-β-aminoalcohols, prominent motifs in pharmaceuticals, bioactive natural products and ligands for transition metals, are thereby accessible with excellent levels of regio-, relative and absolute stereocontrol. |
Dra. Isabel Rozas, Full Professor at the School of Chemistry of the Trinity College (Dublin)
A dónde puede llevarte elegir el ADN como diana biológica
Room 0.6, Edificio Polivalente, UAH. January 11st, 16.00.
On-line: Rozas talk
Last Tuesday, December 12, Dr. Javier Carreras successfully passed hir exam and was appointed as Associate Professor at the UAH.
Congratulations Javi!
