Dr. Merino promoted to Associate Professor at the UAH
Last friday, March 1st, Dr. Estibaliz Merino successfully passed her exam and was appointed as Associate Professor at the UAH.
Congratulations Estíbaliz!
Category Archives: Noticias
SISOC-XIV participation
XIV Spanish-Italian Symposium on Organic Chemistry
Torino, Italy, 25 – 27 February 2024
· Heterodifunctionalization of Alkynes Promoted Exclusively by Visible Light
Clara Mañas, Estíbaliz Merino
Flash communication
Org. Lett 02.24
Visible Light-Mediated Heterodifunctionalization of Alkynylazobenzenes for 2H-Indazole Synthesis
Clara Mañas and Estíbaliz Merino*
Org. Lett. 2024, ASAP
DOI: acs.orglett.4c00097
| We disclose the heterodifunctionalization of alkynylazobenzenes promoted exclusively by visible light in the absence of any transition metal and/or photocatalyst. This reaction features excellent regioselectivity on a broad variety of substrates with perfect atom economy. Alcohols, carboxylic acids, thiols, amides, heterocycles, and even water are suitable substrates for the promotion of the oxyamination, sulfenoamination, and diamination reactions. In this manner, biologically active indazole scaffolds can be rapidly assembled from alkyne feedstocks. |
Francisco Maqueda Zelaya PhD Dissertation Defense
On January 11st, Francisco Maqueda successfully defended his doctoral thesis under the supervision of Prof. Juan José Vaquero and Dr. José Luis Aceña.
Thanks to all members of thesis tribunal: Dr. David Sucunza, Prof. Isabel Rozas and, Dr María Ángeles Castro
Congratulations to Dr. Maqueda!
Nat. Chem. 2024
Chiral arylsulfinylamides as reagents for visible light-mediated asymmetric alkene aminoarylations
Cédric Hervieu, Mariia S. Kirillova, Yawen Hu, Sergio Cuesta-Galisteo, Estíbaliz Merino*, Cristina Nevado
Nat. Chem. 2024, Accepted Articles
DOI: 10.1038/s41557-023-01414-8
| Two- or one-electron-mediated difunctionalizations of internal alkenes represent straightforward approaches to assemble molecular complexity by the simultaneous formation of two contiguous Csp3 stereocentres. Although racemic versions have been extensively explored, asymmetric variants, especially those involving open-shell C-centred radical species, are much more limited both in number and scope. Here we describe enantioenriched arylsulfinylamides as all-in-one reagents for the efficient asymmetric, intermolecular aminoarylation of alkenes. Under mild photoredox conditions, nitrogen addition of the arylsulfinylamide onto the double bond, followed by 1,4-translocation of the aromatic ring, produce, in a single operation, the corresponding aminoarylation adducts in enantiomerically enriched form. The sulfinyl group acts here as a traceless chiral auxiliary, as it is eliminated in situ under the mild reaction conditions. Optically pure β,β-diarylethylamines, aryl-α,β-ethylenediamines and α-aryl-β-aminoalcohols, prominent motifs in pharmaceuticals, bioactive natural products and ligands for transition metals, are thereby accessible with excellent levels of regio-, relative and absolute stereocontrol. |
Dra. Isabel Rozas talk, 11.01.24
Dra. Isabel Rozas
Dra. Isabel Rozas, Full Professor at the School of Chemistry of the Trinity College (Dublin)
A dónde puede llevarte elegir el ADN como diana biológica
Room 0.6, Edificio Polivalente, UAH. January 11st, 16.00.
On-line: Rozas talk
Dr. Carreras promoted to Associate Professor at the UAH
Dr. Carreras promoted to Associate Professor at the UAH
Last Tuesday, December 12, Dr. Javier Carreras successfully passed hir exam and was appointed as Associate Professor at the UAH.
Congratulations Javi!
Adv. Synth. Catal. 2023
Total Synthesis of Laetevirenol A via Regioselective Gold-Catalyzed and Acid-Promoted Cyclizations
Ana Milián, Lucía Sánchez-Jiménez, Jaime Tostado, Juan J. Vaquero, Manuel A. Fernández-Rodríguez*, Patricia García-García*
Adv. Synth. Catal. 2023, Accepted Articles
DOI: 10.1002/adsc.202301136
| The total synthesis of Laetevirenol A, a natural product with antioxidant activity, has been achieved. A gold-catalyzed cycloisomerization of an o-alkenyl-o’-alkynylbiphenyl has been used as the key step for the construction of the phenanthrene moiety present in Laetevirenol A. Several studies in model substrates have been carried out to unveil the effect of substituents in different locations in the outcome of this cyclization, which allowed the design of an appropriate precursor for the fundamental gold-catalyzed cycloisomerization. The suitably functionalized phenanthrene intermediate obtained in this key step could be further transformed into Laetevirenol A via a Friedel-Crafts cyclization, which also turned out to be dependent on the nature of the substituents. Finally, Laetevirenol A was obtained in 10 steps from commercially available substrates, with a 20% global yield. |
Patricia García – junior director’s award in science branches 2023
Dr. Patricia García has received the award for junior director in the area of science, health sciences, engineering and architecture in the 2023 call.
This award is a recognition of the work done by the faculty of the University of Alcalá for obtaining results in the field of research training.
Congratulations!
J. Org. Chem. 09.23
1,2,3-Benzotriazine Synthesis by Heterocyclization of p-Tosylmethyl Isocyanide Derivatives
Francisco Maqueda-Zelaya, José Luis Aceña*, Estíbaliz Merino, Juan J. Vaquero, and David Sucunza*
J. Org. Chem. 2023, ASAP
DOI: 10.1021/acs.joc.3c01675
| An efficient methodology to form 4-alkoxy- and 4-aryloxybenzo[d][1,2,3]triazines via an intramolecular heterocyclization of 1-azido-2-[isocyano(p-tosyl)methyl]benzenes under basic conditions has been developed. DFT calculations have been performed to further understand the mechanism of this heterocyclization, which occurs in good to excellent yields with a broad scope. |