Publications > Sanchez et al
Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold.
Departamento de Quimica Organica, Universidad de Alcala, E-28871 Alcala de Henares, Madrid, Spain. julio.alvarez.@uah.es.
Abstract
A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compounds.
