Sanchez et al. Org Biomol Chem. 2014;12(24):4233-42. Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold.

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Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold.

Departamento de Quimica Organica, Universidad de Alcala, E-28871 Alcala de Henares, Madrid, Spain. julio.alvarez.@uah.es.

Abstract

A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compounds.

graphical abstract