Publicaciones > Deligeorgiev et al

Mini-Reviews in Organic Chemistry. 2010; 7(1):44 -53.

Green chemistry in organic synthesis.

T. Deligeorgiev^1, 2, N. Gadjev, A. Vasilev, S. Kaloyanova, J.J. Vaquero, J. Alvarez-Builla

1. University of Sofia, Faculty of Chemistry, 1164 Sofia, Bulgaria.  2. University of Alcalá, Faculty of Pharmacy, 28871 Alcalá de Henares, Madrid, Spain.

Resumen

The development of the concepts for "Green Chemistry" and the main principles of this field are reviewed. Examples of the application of these principles in different areas of chemistry are included. The frequently used alternative solvents (green solvents - water, PEG, perfluorinated solvents, supercritical liquids) in preparative organic chemistry are described. The present and the future developments of green chemistry in education and organic chemical technology are considered. © 2010 Bentham Science Publishers Ltd.

Publicaciones > Deligeorgiev et al

Coloration Technology. 2010; 126(1):24-30. doi: 10.1111/j.1478-4408.2010.00223.x

Novel environmentally benign procedure for the synthesis of 2-aryl- and 2-hetaryl-4(3H)-quinazolinones

T G Deligeorgiev, St Kaloyanova, A Vasilev, J-J Vaquero, J Alvarez-Builla, Ana M Cuadro

Resumen

A novel environmentally benign procedure for the synthesis of 2-aryl- or 2-hetaryl-4(3H)-quinazolinones by condensation of anthranilamide with various aromatic aldehydes in polyethylene glycol under microwave irradiation has been developed. In contrast with other reported methods, this procedure provides the corresponding quinazolinones with good to high yields and purity, in very short reaction times and without the use of an oxidant.

Publicaciones > Deligeorgiev et al

Ultrasonics Sonochemistry 2010; 17(5):783-788. doi: 10.1016/j.ultsonch.2010.03.002

An easy and fast ultrasonic selective S-alkylation of hetaryl thiols at room temperature

Todor Deligeorgiev, Stefka Kaloyanova, Nedyalko Lesev, Juan J. Vaquero

Palabras clave: Selective S-alkylation; Mercaptoazoles; Ultrasound irradiation

Resumen

A series of 2-alkylthio derivatives of hetaryl thiols were synthesized by selective S-alkylation with alkyl halides (bromides and iodides) with ultrasonic irradiation at room temperature. The reaction was found to be generally applicable to hetaryl thiol derivatives with different substituents in the aromatic nucleus and various alkyl halides. The reaction gives high to excellent yields of products with high purity.