Este año el grupo ha contribuido en dos de sus artículos en portadas de las revistas:
· Chem Med Chem
Pyrrolo[1,2‐a]quinoxalines: Insulin Mimetics that Exhibit Potent and Selective Inhibition against Protein Tyrosine Phosphatase 1B
Javier García‐Marín, Mercedes Griera, Patricia Sánchez‐Alonso, Bruno Di Geronimo, Francisco Mendicuti, Manuel Rodríguez‐Puyol*, Ramón Alajarín*, Beatriz de Pascual‐Teresa, Juan J. Vaquero*, Diego Rodríguez‐Puyol*
| The Front Cover shows a C2C12 cell with the inhibitor 4‐benzylpyrrolo[1,2‐a]quinoxaline targeting the α3/α6/α7 tunnel in the Protein Tyrosine Phosphatase 1B (PTP1B) represented as a ribbon diagram. The insulin receptor (clear green) and the glucose transporter (clear yellow) shown at the cell membrane are involved in the glucose uptake by the cell. The inhibition of PTP1B by this molecule and their analogues produces an insulin mimetic effect. This is indicated by red arrows for the glucose molecules (in sticks) crossing the cell membrane to the cytosol. |
· Org Lett
Selective Synthesis of Phenanthrenes and Dihydrophenanthrenes via Gold-Catalyzed Cycloisomerization of Biphenyl Embedded Trienynes
Ana Milián, Patricia García-García*, Adrián Pérez-Redondo, Roberto Sanz, Juan J. Vaquero, and Manuel A. Fernández-Rodríguez*
| The cover art illustrates the solvent-controlled gold(I)-catalyzed selective synthesis of phenanthrenes and dihydrophenanthrenes from easily available biphenyl-embedded trienynes. Notably, the phenanthrene synthesis developed is complementary to the well-studied strategy that produces regioisomeric phenanthrenes, resulting from the competitive nucleophilic addition of biphenyl to the activated alkyne. In addition, the isolation of the cyclobutenyl derivative depicted in the figure accounts for the participation of cyclobutene species in the catalytic cycle. |
