We are pleased to announce that Dr. Clara Mañas has been awarded the prize for the best doctoral thesis in the Health Sciences category by the Sociedad de Condueños.
Dr. Mañas award-winning thesis, titled “Design and study of novel reactivities of alkynylazobenzenes,” represents a significant contribution to the field. The award recognizes the exceptional quality and originality of her research.
The Society of Condueños Awards are given annually to recognize excellence in academic and cultural fields.The Society collaborates with key institutions in Alcalá to grant these prestigious awards, which celebrate the best doctoral theses across several disciplines at the Universidad de Alcalá
The QuiBio Group is welcoming two new members, Marina and Lorena!
The Biological Chemistry Research Group is thrilled to have two new PhD students join the team as project research associates. Marina will be working with Dr. Javier García Marin on new protein-protein interaction disruptors to fight against fibrosis, while Lorena will be under the supervision of Dr. Ángela Martín-Serrano to discover bifunctional molecules as antibody-recruiting agents.
We wish them both the best of luck with their doctoral theses and are excited to see the contributions they’ll make to our research!
Synthesis of 3,4-Dihydroquinazolinones via Base-Promoted Formal [4 + 2] Cycloadditions
Sergio Torres-Oya, Manuel A. Fernández-Rodríguez, Mercedes Zurro*
Compounds containing tricyclic bridgehead carbon centers are privileged structures in drug discovery. In this work, two different polycyclic scaffolds containing this substructure have been accessed by divergent gold-catalyzed cycloisomerizations of o-cyclopropylidenemethyl-o′-alkynylbiaryls. Selectivity towards one or the other scaffold is mainly controlled by temperature. The electronic nature of the arene group at the alkyne also plays a significant role, which is explained based on the proposed mechanism.
Our group member, Sergio Torres Oya, has participated in the Dream Reactions Symposium 2025 held in Münster (Germany) with a poster.
· Enantioselective copper (ii) catalysed (4+1) cycloaddition of Aza-o-quinone methides and bromomalonates: facile access to chiral Indolines Sergio Torres-Oya, Manuel A. Fernández-Rodríguez, Mercedes Zurro
Divergent synthesis of two polycyclic frameworks containing tricyclic bridgehead carbon centers by gold-catalyzed cycloisomerization of o-cyclopropylidenemethyl-o′-alkynylbiaryls
Lucía Sánchez, Adrián Gargantiel, Manuel A. Fernández-Rodríguez,* Patricia García-García*
Compounds containing tricyclic bridgehead carbon centers are privileged structures in drug discovery. In this work, two different polycyclic scaffolds containing this substructure have been accessed by divergent gold-catalyzed cycloisomerizations of o-cyclopropylidenemethyl-o′-alkynylbiaryls. Selectivity towards one or the other scaffold is mainly controlled by temperature. The electronic nature of the arene group at the alkyne also plays a significant role, which is explained based on the proposed mechanism.
orcid.org/
This inaugural session was organized in collaboration with the EFMC Young Scientists Network (YSN) as part of their #LunchandLearn initiative.