All posts by Javier García Marín

Miembros

Javier Recio

Javier Recio Ramos

Assistant Professor

  • 2024-Present: Assistant Professor at Universidad Rey Juan Carlos.
  • 2024: Postdoctoral researcher ‘Margarita Salas’, at Universidad de Alcalá (Prof.  Manuel Ángel Fernández).
  • 2022-2023: Postdoctoral researcher ‘Margarita Salas’ at CIB-CSIC (Spain) (Prof.  Ana Martínez).
  • 2021: Scientific Supervisor at Centro de Química Aplicada y Biotecnología (CQAB) UAH.
  • 2020-2021: Postdoctoral researcher (ERC-associated project), Universität Hamburg (Germany), (Prof. Axel Jacobi von Wangelin).
  • 2020 PhD in Medicinal Chemistry (FPI-UAH grant) at Universidad de Alcalá, (Prof. Julio Álvarez / Prof. Carolina Burgos).
  • 2018: Predoctoral research stay, Universität Hamburg (Germany) (Prof. Axel Jacobi von Wangelin).
  • 2015 Master in Química Fina by Universidad de Alcalá (Spain).
  • 2014: Graduted (Chemistry) at Universidad de Alcalá (Spain).
Uncategorized

Ángela Belén Ibarra

  • FPI (project-associated), Universidad de Alcalá (2022-2023)
  • Master Organic Chemsitry, Universidad Autónoma de Madrid (2022-2023)
  • Graduated (Chemistry), Universidad Autónoma de Madrid (2018-2022)

Publications in the group

Shaping cycles with light: a regiodivergent approach to tetracyclic aza-aromatic compounds.
Clara Mañas, Belén Ibarra, Estíbaliz Merino
Org. Chem. Front., 2024,11, 6974-6988.
Miembros

Carmen Callejón

Carmen Callejón Martínez

  • Project associate researcher Universidad de Alcalá (2022)
  • “Contrato Yo Investigo” researcher at Universidad de Alcalá (2021 2022)
  • Master Applied and Pharmacological Chemistry, Universidad de Castellón (2020/2021)
  • Graduated (Cehmistry) at the Universidad de Jaen (2019)
Miembros

Sergio Torres

Sergio Torres

ORCID iD iconorcid.org/0000-0002-1003-519X

  • Project associate researcher FIBioHRC Universidad de Alcalá (2022-2023)
  • “Contrato Yo Investigo” researcher at Universidad de Alcalá (2021 2022)
  • Master Drug Discovery, Universidad Complutense (2021/2022)
  • Master in Industrial Chemistry and Introduction to the Chemical Research, Universidad Autónoma de Barcelona (2017-2018)
  • Graduated in Chemistry at the Universidad Autónoma de Barcelona (2013-2017)

Publications in the group

Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides.
Mercedes Zurro, Sergio Torres-Oya, Estíbaliz Merino
Eur. J. Chem. 2023, e202300535.
Visible-Light-Mediated Regioselective Chlorosulfonylation of Acrylamides.
Mercedes Zurro, Sergio Torres-Oya, Guillermo G. Otárola, Juan José Vaquero, Estíbaliz Merino
Synthesis 2023, 55, 1783
Noticias

Nat. Chem. 2024

Chiral arylsulfinylamides as reagents for visible light-mediated asymmetric alkene aminoarylations

Cédric Hervieu, Mariia S. Kirillova, Yawen Hu, Sergio Cuesta-Galisteo, Estíbaliz Merino*, Cristina Nevado

Nat. Chem. 2024, Accepted Articles
DOI: 10.1038/s41557-023-01414-8

Two- or one-electron-mediated difunctionalizations of internal alkenes represent straightforward approaches to assemble molecular complexity by the simultaneous formation of two contiguous Csp3 stereocentres. Although racemic versions have been extensively explored, asymmetric variants, especially those involving open-shell C-centred radical species, are much more limited both in number and scope. Here we describe enantioenriched arylsulfinylamides as all-in-one reagents for the efficient asymmetric, intermolecular aminoarylation of alkenes. Under mild photoredox conditions, nitrogen addition of the arylsulfinylamide onto the double bond, followed by 1,4-translocation of the aromatic ring, produce, in a single operation, the corresponding aminoarylation adducts in enantiomerically enriched form. The sulfinyl group acts here as a traceless chiral auxiliary, as it is eliminated in situ under the mild reaction conditions. Optically pure β,β-diarylethylamines, aryl-α,β-ethylenediamines and α-aryl-β-aminoalcohols, prominent motifs in pharmaceuticals, bioactive natural products and ligands for transition metals, are thereby accessible with excellent levels of regio-, relative and absolute stereocontrol.