Category Archives: 2026

2026, Au, Publicación

Mañas and. Trends in Chemistry. 2026;8(2):149. Divergent heterocycle synthesis enabled by switchable reaction of azobenzenes with alkynes.

Publications > Mañas and

Trends in Chemistry. 2026; 8(2):149.

Divergent heterocycle synthesis enabled by switchable reaction of azobenzenes with alkynes.

Clara Mañas, Estíbaliz Merino

Resumen

Azobenzenes are long-standing photochromic switches now emerging as synthetic reagents.Their reactions with alkynes enable efficient access to diverse nitrogen heterocycles.Distinct activation modes (metal, photoredox, thermal) dictate divergent reaction pathways.Mechanistic studies reveal complementary polar and radical manifolds.This reactivity opens new opportunities in drug discovery and molecular materials.

2026, Au, Publicación

Tostado et al. Org Biomol Chem. 2026;24(1):80-86. Selective synthesis of 4,5-dihydropyrenes by a Brønsted acid-catalyzed.

Publications > Tostado et al

Org Biomol Chem. 2026 Jan 7;24(1):80-86. doi: 10.1039/d5ob01626f. PubMed 41311167

Selective synthesis of 4,5-dihydropyrenes by a Brønsted acid-catalyzed.

Jaime Tostado, Lucía Sánchez-Jiménez, Manuel A Fernández-Rodríguez

Universidad de Alcalá (IRYCIS). Departamento de Química Orgánica y Química.

Abstract

A metal-free Brønsted acid-catalyzed cascade cyclization enables the selective

2026, Publicación, TosMIC

García-García et al. Org Lett. 2026;28(3):907-911. Synthesis of Multisubstituted Pyridines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Caerulomycins A and K.

Publications > García-García et al

Org Lett. 2026 Jan 23;28(3):907-911. doi: 10.1021/acs.orglett.5c04454. Epub 2025 Dec 3. PubMed 41338582

Synthesis of Multisubstituted Pyridines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Caerulomycins A and K.

José A García-García, José Luis Aceña, Patricia García-García, David Sucunza

Departamento de Química Orgánica y Química Inorgánica, Instituto de Investigación Química "Andrés M. del Río" (IQAR), Universidad de Alcalá, IRYCIS, 28805 Alcalá de Henares, Madrid, Spain.

Abstract

A concise synthesis of multisubstituted pyridines from α-allylic TosMIC derivatives and electrophiles is reported. The process involves a tandem heterocyclization exploiting the dual reactivity of the isocyanide group. The methodology tolerates various electrophiles, including halogen sources, and proceeds under mild conditions. Its utility is showcased in the total synthesis of caerulomycins A and K, in only five steps from TosMIC.