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Divergent heterocycle synthesis enabled by switchable reaction of azobenzenes with alkynes.
Resumen
Azobenzenes are long-standing photochromic switches now emerging as synthetic reagents.Their reactions with alkynes enable efficient access to diverse nitrogen heterocycles.Distinct activation modes (metal, photoredox, thermal) dictate divergent reaction pathways.Mechanistic studies reveal complementary polar and radical manifolds.This reactivity opens new opportunities in drug discovery and molecular materials.