Archivo de la categoría: Noticias

Noticias

Participación congresos

23rd Tetrahedron Symposium

Gothenburg, Sweden, 27 – 30 junio

– Póster:
· Visible light as a single reagent to promote new transformations in azobenzenes
Clara Mañas, Estíbaliz Merino

– Póster:
· Synthesis of 5-aryl-3-trifluoromethylpyrazoles: one-pot [3+2] cycloaddition-isomerization-oxidation
Julia Altarejos, Estíbaliz Merino, David Sucunza, Juan José Vaquero, Javier Carreras

– Póster:
· Synthesis of borylated polycycles by metal-free borylative cyclization of enynes
Ana Milián, Ester Sans-Panadés, Marcos Humanes, Cintia Virumbrales, Estíbaliz Merino, Roberto Sanz, Juan J. Vaquero, Manuel A. Fernández-Rodríguez, Patricia García-García

– Póster:
· Ir-Catalyzed C−H Borylation of 4a,8a-Dihydro-4a-Aza-8a-Boranaphthalene
Isabel Valencia, Patricia Garcia-Garcia, David Sucunza, Francisco Mendicuti, Juan J. Vaquero

XXXIX Reunión Bienal de la RSEQ

Zaragoza, 27 – 30 junio

– Póster:
· Visible Light Na2Eosin Y Catalysed Hydroxysulfonylation of Acrylamides. Straightforward Access to Anticancer Drug Bicalutamide
Mercedes Zurro, Sergio Torres-Oya, Estibaliz Merino*

– Póster/Flash:
· BF3-promoted cascade cyclization of biaryl embedded 1,8-enynes
Jaime Tostado, Juan J. Vaquero, Manuel A. Rodríguez

– Póster:
· Synthesis of benzo[1.2.3]triazines by heterocyclization of TOSMIC derivatives
Francisco Maqueda, David Sucunza, José Luis Aceña, Juan José Vaquero

– Póster/Flash:
· Synthesis of polycyclic hydrocarbons by gold-catalyzes tandem formation of 4-, 5- and 7-membered rings
L. Sánchez-Jiménez, A. Gargantiel, P. García-García, M. A. Fernández-Rodríguez

– Póster/Flash:
· Towards new peptide-based compounds: synthesis of a series of novel bicyclic amino acids
Álvaro González-Molina, José Luis Aceña y Juan José Vaquero

– Póster/Flash:
· New photoreactivity of azobenzenes towards complex N-heterocycles
Clara Mañas, Estíbaliz Merino

IX Symposium of Medicinal Chemistry Young Researchers

Santiago de Compostela, 22 junio

· Novel bicyclic amino acids as potential building blocks for new peptidomimetics
Álvaro González-Molina, José Luis Aceña y Juan José Vaquero

Noticias

Nuevo artículo, ACS Macro Lett. 06.2023

Hyper-Cross-Linked Porous Polymer Featuring B–N Covalent Bonds (HCP-BNs): A Stable and Efficient Metal-Free Heterogeneous Photocatalyst

Sara Señorans, Isabel Valencia, Estíbaliz Merino, Marta Iglesias, Manuel A. Fernández-Rodríguez*, Eva M. Maya*

ACS Macro Lett. 2023, ASAP
DOI: 10.1021/acsmacrolett.3c00217

The first example of a porous polymer containing B–N covalent bonds, prepared from a tetraphene B–N monomer and biphenyl as a comonomer, is reported. It was prepared using the solvent knitting strategy, which allows the connection between the aromatic rings of the two monomers through methylene groups provided by an external cross-linking agent. The new polymer exhibited micromeso porosity with an SBET of 612 m2/g, high thermal stability, and potential properties as a heterogeneous photocatalyst, since it is very active in the aza-Henry coupling reaction (>98% of conversion and selectivity). After the first run, the catalyst improves its photocatalytic activity, shortening the reaction time to only 2 h and maintaining this activity in successive runs. The presence of a radical in this structure that remains stable with successive runs makes it a new type of material with potential applications as a highly stable and efficient photocatalyst.
Noticias

Nuevo artículo, ChemSusChem 05.23

Mizoroki–Heck Macrocyclization Reactions at 1 M Concentration Catalyzed by Sub-nanometric Palladium Clusters

Francisco Garnes–Portolés, Estíbaliz Merino, Antonio Leyva–Pérez*

ChemSusChem 2023, Accepted Articles
DOI: 10.1002/cssc.202300200

Mizoroki-Heck macrocyclization reactions are carried out at 1M concentration with ligand-free Pd cluster catalysts either in solution or supported on solids. Mechanistic studies unveil the essential role of the fluxional Pd cluster to accommodate, at the same time, the reacting groups, to give the intramolecular vs the intermolecular coupling reaction at this high concentration, enabling (in-flow) solid-catalyzed macrocyclization reactions.
Noticias

Nuevo artículo, Synthesis 03.23

Visible-Light-Mediated Regioselective Chlorosulfonylation of Acrylamides

Mercedes Zurro, Sergio Torres-Oya, Guillermo G. Otárola, Juan José Vaquero, Estíbaliz Merino*

Synthesis 2023, Special Issue dedicated to Prof. Cristina Nevado, recipient of the 2021 Dr. Margaret Faul Women in Chemistry Award
DOI: 10.1055/s-0042-1751424

A one-step chlorosulfonylation of acrylamides via a photocatalytic redox process is described. This reaction provides α-chlorosulfonylamides with a quaternary center with high regioselectivity via radical process. It is amenable to a broad range of substrates and the products are obtained in moderate to good yields.
Noticias

Nuevo artículo, Org. Biomol. Chem. 03.23

Gold-catalyzed endo-selective cyclization of alkynylcyclobutanecarboxamides: synthesis of cyclobutane-fused dihydropyridones

M. Soledad Garre, Guillermo G. Otárola, Estíbaliz Merino, David Sucunza, Enrique Aguilar, M. Teresa Quirós, Juan J. Vaquero* and Patricia García-García*

Org. Biomol. Chem. 2023, Advance Article
DOI: 10.1039/D3OB00051F

Cyclobutane-fused dihydropyridones can be efficiently synthesized by a completely endo-selective gold-catalyzed cyclization of alkynylcyclobutanes bearing an appended amide, which proceeds under mild conditions. The observed selectivity, which is reversed from that previously observed for the cyclization of related alcohols and acids, is supported by DFT calculations.
Noticias

Participación XVIII SJIQ

XVIII Simposio de Jóvenes Investigadores Químicos de la RSEQ

Sevilla, 21 – 28 noviembre

– Oral:
· Metal-free synthesis of 3-trifluoromethypyrazoles: [3+2] cyclization of styrenes and 2,2,2-trifluorodiazoethane
Julia Altarejos, David Sucunza, Juan J. Vaquero, Estíbaliz Merino, and Javier Carreras

– Póster:
· Visible-light mediated synthesis of indazoles
Clara Mañas, Estíbaliz Merino

– Póster:
· Synthesis of novel five membered organoborate heterocycles and their use in cross-coupling reactions
Isabel Valencia, Patricia Garcia-Garcia, David Sucunza, Adrián Pérez-Redondo, Juan J. Vaquero



Noticias

Nuevo artículo, Synthesis 11.22

Synthesis of five-membered organoborate heterocycles via a metal-free carboboration and their use in cross-coupling reactions

Isabel Valencia, David Sucunza, Patricia García-García, Adrián Pérez-Redondo, Juan Vaquero López

Synthesis 2022, Accepted Articles
DOI: 10.1055/a-1979-6009

Treatment of various vinylbenzopyridines with allyl(dichloro)borane affords five-membered organoborate heterocycles via a metal-free carboboration. The reaction between these organoborates and Grignard reagents increases the number of derivatives belonging to this novel family of four-coordinate organoboron compounds. Some of them were used as reagents in phenylations and methylations in moderate to high yields under standard palladium-catalyzed cross-coupling reaction conditions.
Noticias

Nuevo artículo, Adv. Synth. Catal. 10.22

Synthesis of Phenanthrene-based Polycycles by Gold(I)-Catalyzed Cyclization of Biphenyl-Embedded Trienynes

Ana Milián, Patricia García-García,* Juan J. Vaquero, Roberto Sanz, Manuel Ángel Fernández-Rodríguez*

Adv. Synth. Catal. 2022, Accepted Articles
DOI: 10.1002/adsc.202200887

Gold(I)-catalyzed cyclization of o-alkenyl-o’-alkynylbiaryls in the presence of external or internal nucleophiles provides a straightforward access to phenanthrene-based polycycles, which are of considerable interest in materials science. Thus, their reactions with alcohols yield functionalized dihydrophenanthrenes, in a process that can also be carried out intramolecularly to provide phenanthrene-derived heteropolycyclic compounds. Moreover, benzo[b]triphenylenes can be synthesized from o-methoxyvinyl-o’-alkynylbiaryls, in a reaction in which an (hetero)aryl substituent at the triple bond acts as an internal nucleophile.