Miembros

Juan José Vaquero

Juan José Vaquero López
Responsable del grupo
Catedrático Universidad de Alcalá

ublons: E-8310-2012

• Profesor Emérito en la Universidad de Alcalá (2023)
• Catedrático de Química Orgánica en la Universidad de Alcalá (1998)
• Profesor Adjunto en la Universidad de Alcalá (1986)
• Profesor adjunto interino (1982-1986) en la Universidad de Alcalá
• Estancia postdoctoral (1985-1986) en el Imperial College en el grupo del Prof. Charles Rees (Londres)
• Becario del Plan de Formación de Personal Investigador (FPI) del Ministerio de Educación y Ciencia (1978-1981) en el Departamento de Química de la Universidad de Alcalá.
• Licenciatura en Ciencias Químicas (1976) en la Facultad de Ciencias Químicas de la Universidad Complutense de Madrid.

Responsable del grupo de investigación de Química Biológica, creado en el año 1995, que agrupa a químicos, farmacéuticos y biólogos moleculares desarrollando proyectos en el campo de la Química Médica, Química Heterocíclica y Bioorgánica. En este tiempo se ha realizado investigación en distintas líneas entre las que destacan por su duración y resultados: Química y aplicaciones de cationes heteroaromáticos en tinción celular y bioimagen, síntesis de heterociclos y alcaloides bioactivos, diseño y síntesis de compuestos biactivos frente a dianas implicadas en la enfermedad renal y química y aplicaciones de azaborinos.
En este periodo ha participado en 27 proyectos de I+D+i financiados en convocatorias competitivas de Administraciones públicas (Plan Nacional, Comunidad Autónoma de Madrid, Instituto de Salud Carlos III (RETICS), INNPACTO) habiendo actuado como IP en 18 de estos proyectos. Ha participado en 59 contratos, convenios o proyectos de I+D+i no competitivos financiados con administraciones y entidades públicas y empresas privadas actuando como IP en 43 de estos contratos/proyectos. Los resultados obtenidos se resumen en 175 publicaciones en revistas indexadas en JCR, 29 patentes (2 internacionales, 4 PCT), 220 contribuciones a congresos nacionales e internacionales y la dirección de 24 Tesis Doctorales, 10 Tesinas y 8 Trabajos Fin de Master.
Ha participado como coautor en tres capítulos de libro publicados por editoriales internacionales (Jai Press LTD, UK y Wiley-VCH Verlag) y coeditor junto con el Prof. Jose Barluenga y el Prof. Julio Alvarez-Builla de los 4 volúmenes de la obra Modern Heterocyclic Chemistry. pp. 1 – 2445 (Alemania), WILEY-VCH Verlag GmbH & Co. KGaA (2011).
Ha desempeñado los cargos académicos de Decano de la Facultad de Química de la Universidad de Alcalá (2000-2006), Vicedecano de la Facultad de Ciencias (1987-2000), Director Científico del Centro de Química Aplicada y Biotecnología de la Universidad de Alcalá (2009-2011, 2012-2014, 2015-2017, 2018…), Coordinador por la Universidad de Alcalá del Master Interuniversitario en Descubrimiento de Fármacos (2013…) y Patrono nombrado por la Universidad de Alcalá en el Patronato del Instituto IMDEA-AGUA de la Comunidad de Madrid (2009…). También ha presidido la Sección Territorial de Madrid de la Real Sociedad Española de Química en el periodo 2006-2011.

Publicaciones en el grupo

1,2,3-Benzotriazine Synthesis by Heterocyclization of p-Tosylmethyl Isocyanide Derivatives.
Francisco Maqueda-Zelaya, José Luis Aceña, Estíbaliz Merino, Juan J. Vaquero, David Sucunza
The Journal of Organic Chemistry. 2023; 88(19):14131 -14139.
One-Pot (3 + 2) Cycloaddition-Isomerization-Oxidation of 2,2,2-Trifluorodiazoethane and Styryl Derivatives.
Julia Altarejos, Estíbaliz Merino, David Sucunza, Juan J Vaquero, Javier Carreras
J Org Chem. 2023, doi: 10.1021/acs.joc.3c00396.
β-Functionalization of 4 a-aza-8 a-boranaphthalene via Iridium-catalyzed C−H Borylation /
Isabel Valencia, David Sucunza, Francisco Mendicuti, Patricia García-García, Juan J. Vaquero
Adv. Synth.Catal. 2023; Early View
Visible-Light-Mediated Regioselective Chlorosulfonylation of Acrylamides.
Mercedes Zurro, Sergio Torres-Oya, Guillermo G. Otárola, Juan José Vaquero, Estíbaliz Merino
Synthesis 2023, DOI: 10.1055/s-0042-1751424.
Gold-catalyzed endo-selective cyclization of alkynylcyclobutanecarboxamides: synthesis of cyclobutane-fused dihydropyridones.
M Soledad Garre, Guillermo G Otárola, Estíbaliz Merino, David Sucunza, Enrique Aguilar, M Teresa Quirós, Juan J Vaquero, Patricia García-García
Org Biomol Chem. 2023,21,2705-2708. doi: 10.1039/d3ob00051f.
Synthesis of Five-Membered Organoborate Heterocycles via a Metal-Free Carboboration and Their Use in Cross-Coupling Reactions.
Isabel Valencia, David Sucunza, Patricia García-García, Adrián Pérez-Redondo, Juan J. Vaquero
Synthesis 2023, 55, 1260-1266. doi: 10.1055/a-1979-6009
Synthesis of Phenanthrene-Based Polycycles by Gold(I)-Catalyzed Cyclization of Biphenyl-Embedded Trienynes.
Ana Milián, Patricia García-García, Juan J. Vaquero, Roberto Sanz, Manuel A. Fernández-Rodríguez
Adv. Synth. Catal. 2022; 364, 3960-3966, doi:10.1002/adsc.202200887.
Highly efficient unbridged D-A%@2B(D) chromophores based on the quinolizinium cation for nonlinear optical (NLO) applications /
Esmeralda Sánchez-Pavón, Javier Recio, Marco Antonio Ramirez, Belen Batanero, Koen Clays, Francisco Mendicuti, Gema Marcelo, Thais Carmona, Obis Castaño, Silvia Angelova, Jose L. Andres, Juan J. Vaquero, Ana M. Cuadro
Dyes and Pigments 2022, 205, 110323. doi: 10.1016/j.dyepig.2022.110323.
Synthesis of BN-Polyarenes by a Mild Borylative Cyclization Cascade.
Ester Sans-Panadés, Juan J Vaquero, Manuel A Fernández-Rodríguez, Patricia García-García
Org Lett. 2022;24(31):5860-5865. doi: 10.1021/acs.orglett.2c02477.
Steviol glycosides as an alternative osmotic agent for peritoneal dialysis fluid.
Valeria Kopytina, Lucía Pascual-Antón, Nora Toggweiler, Eva-María Arriero-País, Lisa Strahl, Patricia Albar-Vizcaíno, David Sucunza, Juan J Vaquero, Sonja Steppan, Dorothea Piecha, Manuel López-Cabrera, Guadalupe-Tirma González-Mateo
Front Pharmacol. 2022 Aug 16;13:868374. doi: 10.3389/fphar.2022.868374. eCollection 2022.
Insight into the mechanism of molecular recognition between human Integrin-Linked Kinase and Cpd22 and its implication at atomic level.
Javier García-Marín, Diego Rodríguez-Puyol, Juan J Vaquero
J Comput Aided Mol Des. 2022 Aug;36(8):575-589. doi: 10.1007/s10822-022-00466-1.
Metal-Free Temperature-Controlled Regiodivergent Borylative Cyclizations of Enynes: BCl(3) -Promoted Skeletal Rearrangement.
Ana Milián, Manuel A Fernández-Rodríguez, Estíbaliz Merino, Juan J Vaquero, Patricia García-García
Angew Chem Int Ed Engl. 2022 May 5:e202205651. doi: 10.1002/anie.202205651.
Pyridazino-pyrrolo-quinoxalinium salts as highly potent and selective leishmanicidal agents targeting trypanothione reductase.
Héctor de Lucio, Javier García-Marín, Patricia Sánchez-Alonso, Juan Carlos García-Soriano, Miguel Ángel Toro, Juan J Vaquero, Federico Gago, Ramón Alajarín, Antonio Jiménez-Ruiz
Eur J Med Chem. 2022 Jan 5;227:113915. doi: 10.1016/j.ejmech.2021.113915.
1,10a-Dihydro-1-aza-10a-boraphenanthrene and 6a,7-Dihydro-7-aza-6a-boratetraphene: Two New Fluorescent BN-PAHs.
Isabel Valencia, Patricia García-García, David Sucunza, Francisco Mendicuti, Juan J Vaquero
J Org Chem. 2021 Nov 22. doi: 10.1021/acs.joc.1c01095.
Two-photon activated precision molecular photosensitizer targeting mitochondria.
Inês F. A. Mariz, Sandra N. Pinto, Ana M. Santiago, José M. G. Martinho, Javier Recio, Juan J. Vaquero, Ana M. Cuadro, Ermelinda Maçôas
Commun. Chem. 2021; 4(1):142. doi: 10.1038/s42004-021-00581-4
A Computer-Driven Scaffold-Hopping Approach Generating New PTP1B Inhibitors from the Pyrrolo%1,2-a%quinoxaline Core.
Javier García-Marín, Mercedes Griera, Ramón Alajarín, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Juan J Vaquero
ChemMedChem. 2021 Sep 16;16(18):2895-2906. doi: 10.1002/cmdc.202100338. Epub 2021 Jul 19.
Enantioselective Copper-Catalyzed Synthesis of Trifluoromethyl-Cyclopropylboronates.
Julia Altarejos, David Sucunza, Juan J Vaquero, Javier Carreras
Org Lett. 2021 Aug 6;23(15):6174-6178. doi: 10.1021/acs.orglett.1c02420.
Pyrrolo%1,2-a%quinoxal-5-inium salts and 4,5-dihydropyrrolo%1,2-a%quinoxalines: Synthesis, activity and computational docking for protein tyrosine phosphatase 1B.
Patricia Sánchez-Alonso, Mercedes Griera, Javier García-Marín, Manuel Rodríguez-Puyol, Ramón Alajarín, Juan J Vaquero, Diego Rodríguez-Puyol
Bioorg Med Chem. 2021 Jul 3; 44:116295.
Tripeptides as Integrin-Linked Kinase Modulating Agents Based on a Protein-Protein Interaction with α-Parvin.
Javier Garcia-Marin, Mercedes Griera-Merino, Alejandra Matamoros-Recio, Sergio de Frutos, Manuel Rodríguez-Puyol, Ramón Alajarín, Juan J Vaquero, Diego Rodríguez-Puyol
ACS Med Chem Lett. 2021 Jul 15;12(11):1656-1662. doi: 10.1021/acsmedchemlett.1c00183.
Recent developments in the chemistry of BN-aromatic hydrocarbons.
Alberto Abengozar, Patricia Garcia-Garcia, Manuel A. Fernández-Rodríguez, David Sucunza, Juan J Vaquero
Adv. Heterocycl. Chem. 2021 Mar 28; :197-259.
A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding properties.
Pedro Bosch, Gema Marcelo, Alejandra Matamoros-Recio, David Sucunza, Francisco Mendicuti, Alberto Domingo, Juan J Vaquero
Dyes and Pigments. 2021 Aug 1; :109443. doi: 10.1016/j.dyepig.2021.109443
Selective Synthesis of Phenanthrenes and Dihydrophenanthrenes via Gold-Catalyzed Cycloisomerization of Biphenyl Embedded Trienynes.
Ana Milián, Patricia García-García, Adrián Pérez-Redondo, Roberto Sanz, Juan J Vaquero, Manuel A Fernández-Rodríguez
Org Lett. 2020 Nov 6;22(21):8464-8469. doi: 10.1021/acs.orglett.0c03067.
Gold-Catalyzed Synthetic Strategies towards Four-Carbon Ring Systems.
Guillermo G Otarola, Juan J Vaquero, Estíbaliz Merino, Manuel A Fernández-Rodríguez
Catalysts. 2020 Oct 8; 22(21):1178.
Pyrrolo%1,2-a%quinoxalines: Insulin Mimetics that Exhibit Potent and Selective Inhibition against Protein Tyrosine Phosphatase 1B.
Javier García-Marín, Mercedes Griera, Patricia Sánchez-Alonso, Bruno Di Geronimo, Francisco Mendicuti, Manuel Rodríguez-Puyol, Ramón Alajarín, Beatriz de Pascual-Teresa, Juan J Vaquero, Diego Rodríguez-Puyol
ChemMedChem. 2020 Sep 10. doi: 10.1002/cmdc.202000446.
The pHLIP system as a vehicle for microRNAs in the kidney.
Verónica Miguel, Carlos Rey, José Luis Aceña, Francisco Maqueda, Carlos Fernández-Hernando, Diego Rodríguez-Puyol, Juan J Vaquero, Santiago Lamas
Nefrologia. 2020 Jul 18:S0211-6995(20)30084-9. doi: 10.1016/j.nefro.2020.05.007.
Practical Solvent-Free Microwave-Assisted Hydroboration of Alkynes.
Julia Altarejos, David Sucunza, Juan J Vaquero, Javier Carreras
Eur. J. Org. Chem. 2020 May 26:3024-3029. doi: 10.1002/ejoc.202000110.
Expanding the BN-embedded PAH family: 4a-aza-12a-borachrysene.
Alberto Abengozar, Isabel Valencia, Guillermo G Otarola, David Sucunza, Patricia Garcia-Garcia, Adrian Perez-Redondo, Francisco Mendicuti, Juan J Vaquero
Chem Commun (Camb). 2020 Mar 28;56(25):3669-3672. doi: 10.1039/c9cc09998k.
Synthesis and Photophysical Behavior of a Highly Fluorescent Family of Unsymmetrical Organoboron Complexes Containing 5-(Pyridin-2-ylmethylene)imidazolidine-2,4-dione Moieties.
M Soledad Garre, Raul Losantos, Sara Gutierrez, David Sucunza, Patricia Garcia-Garcia, Diego Sampedro, Juan J Vaquero
J Org Chem. 2020 Jan 17;85(2):441-448. doi: 10.1021/acs.joc.9b02451.
A New Member of the BN-Phenanthrene Family: Understanding the Role of the B-N Bond Position.
Alberto Abengozar, David Sucunza, Patricia Garcia-Garcia, Diego Sampedro, Adrian Perez-Redondo, Juan J Vaquero
J Org Chem. 2019 Jun 7;84(11):7113-7122. doi: 10.1021/acs.joc.9b00800. Epub 2019 May 23.
Remarkable effect of alkynyl substituents on the fluorescence properties of a BN-phenanthrene.
Alberto Abengozar, David Sucunza, Patricia Garcia-Garcia, Juan J Vaquero
Beilstein J Org Chem. 2019 Jun 6;15:1257-1261. doi: 10.3762/bjoc.15.122. eCollection 2019.
NIK as a Druggable Mediator of Tissue Injury.
Lara Valino-Rivas, Juan Jose Vaquero, David Sucunza, Sara Gutierrez, Ana B Sanz, Manuel Fresno, Alberto Ortiz, Maria Dolores Sanchez-Nino
Trends Mol Med. 2019 Apr;25(4):341-360. doi: 10.1016/j.molmed.2019.02.005. Epub 2019 Mar 26.
Synthesis, Functionalization, and Optical Properties of 1,2-Dihydro-1-aza-2-boraphenanthrene and Several Highly Fluorescent Derivatives.
Alberto Abengozar, Patricia Garcia-Garcia, David Sucunza, Diego Sampedro, Adrian Perez-Redondo, Juan J Vaquero
Org Lett. 2019 Apr 19;21(8):2550-2554. doi: 10.1021/acs.orglett.9b00448. Epub 2019 Apr 5.
Regiodivergent Electrophilic Cyclizations of Alkynylcyclobutanes for the Synthesis of Cyclobutane-Fused O-Heterocycles.
M Soledad Garre, David Sucunza, Enrique Aguilar, Patricia Garcia-Garcia, Juan J Vaquero
J Org Chem. 2019 Apr 18. doi: 10.1021/acs.joc.9b00618.
MAP3K kinases and kidney injury.
Leticia Cuarental, David Sucunza-Saenz, Lara Valino-Rivas, Beatriz Fernandez-Fernandez, Ana Belen Sanz, Alberto Ortiz, Juan Jose Vaquero, Maria Dolores Sanchez-Nino
Nefrologia. 2019 Nov - Dec;39(6):568-580. doi: 10.1016/j.nefro.2019.03.004.
Discovery of potent calpain inhibitors based on the azolo-imidazolidenone.
Sara Gutierrez, Maria Moron, Mercedes Griera, David Sucunza, Laura Calleros, Andrea Garcia-Jerez, Claire Coderch, Francisco J Hermoso, Carolina Burgos, Manuel Rodriguez-Puyol, Beatriz de Pascual-Teresa, Maria L Diez-Marques, Antonio Jimenez, Miguel Toro-Londono, Diego Rodriguez-Puyol, Juan J Vaquero
Eur J Med Chem. 2018 Sep 5;157:946-959. doi: 10.1016/j.ejmech.2018.08.045.
C-H Functionalization of BN-Aromatics Promoted by Addition of Organolithium Compounds to the Boron Atom.
Alberto Abengozar, Miguel Angel Fernandez-Gonzalez, David Sucunza, Luis Manuel Frutos, Antonio Salgado, Patricia Garcia-Garcia, Juan J Vaquero
Org Lett. 2018 Aug 17;20(16):4902-4906. doi: 10.1021/acs.orglett.8b02040.
gamma-Carboline Synthesis by Heterocyclization of TosMIC Derivatives.
Sara Gutierrez, David Sucunza, Juan J Vaquero
J Org Chem. 2018 Jun 15;83(12):6623-6632. doi: 10.1021/acs.joc.8b00906. Epub 2018 May 24.
A Tricin Derivative from Deschampsia antarctica Desv. Inhibits Colorectal Carcinoma Growth and Liver Metastasis through the Induction of a Specific Immune Response.
Mariana Malvicini, Ana Gutierrez-Moraga, Marcelo M Rodriguez, Sofia Gomez-Bustillo, Lorena Salazar, Carlos Sunkel, Leonor Nozal, Antonio Salgado, Manuel Hidalgo, Pedro P Lopez-Casas, Jose Luis Novella, Juan Jose Vaquero, Julio Alvarez-Builla, Adda Mora, Manuel Gidekel, Guillermo Mazzolini
Mol Cancer Ther. 2018 May;17(5):966-976. doi: 10.1158/1535-7163.MCT-17-0193.
Dibenzopyridoimidazocinnolinium cations: a new family of light-up fluorescent DNA probes.
Pedro Bosch, David Sucunza, Francisco Mendicuti, Alberto Domingo, Juan J Vaquero
Org. Chem. Front. 2018 May 2; 5(12):1916-1927. doi: 10.1039/C8QO00236C
Synthesis of functionalized helical BN-benzo%c%phenanthrenes.
Alberto Abengozar, Patricia Garcia-Garcia, David Sucunza, Adrian Perez-Redondo, Juan J Vaquero
Chem Commun (Camb). 2018 Mar 6;54(20):2467-2470. doi: 10.1039/c7cc09264d.
Azonia aromatic heterocycles as a new acceptor unit in D-π-A+ vs D-A+ nonlinear optical chromophores.
Tatiana Cañeque, Ana M. Cuadro, Raúl Custodio, Julio Alvarez-Builla, Belén Batanero, Pilar Gómez-Sal, Javier Pérez-Moreno, Koen Clays, Obis Castaño, José L. Andrés, Thais Carmona, Francisco Mendicuti, Juan J Vaquero
Dyes & Pigments, 2017 Sep 1;144:17-31. doi: 10.1016/10.1016/j.dyepig.2017.05.005.
Microwave-assisted pyrolysis of Mediterranean forest biomass waste: Bioproduct characterization.
María T. Martín, Ana B. Sanz, Leonor Nozal, Flor Castro, Raúl Alonso, Juan L. Aguirre, Sergio D. González, M. Paz Matía, José L. Novella, Manuel Peinado, Juan J Vaquero
J. Anal. Appl. Pyrolysis, 2017 Sep 1;127:278-285. doi: j.jaap.2017.07.024.
Synthesis, Optical Properties, and Regioselective Functionalization of 4a-Aza-10a-boraphenanthrene.
Alberto Abengozar, Patricia Garcia-Garcia, David Sucunza, Luis Manuel Frutos, Obis Castano, Diego Sampedro, Adrian Perez-Redondo, Juan J Vaquero
Org Lett. 2017 Jul 7;19(13):3458-3461. doi: 10.1021/acs.orglett.7b01435.
Imidazopyridinium cations: A new family of azonia aromatic heterocycles with applications as DNA intercalators.
Pedro Bosch, Verónica García, Başak S.Bilen, David Sucunza, Alberto Domingo, Francisco Mendicuti, Juan J Vaquero
Dyes & Pigments, 2017 Mar 1;138:135-146. doi: 10.1016/j.dyepig.2016.11.041.
Quinolizinium as a new fluorescent lysosomotropic probe.
Emmanouil Zacharioudakis, Tatiana Cañeque, Raúl Custodio, Sebastian Müller, Ana M. Cuadro, Juan J Vaquero, Raphaël Rodriguez
Biorg. Med. Chem. Lett., 2017 Jan 15;27(2):203-207. doi: 10.1016/j.bmcl.2016.11.074.
Halogen-containing thiazole orange analogues - new fluorogenic DNA stains.
Aleksey A Vasilev, Meglena I Kandinska, Stanimir S Stoyanov, Stanislava B Yordanova, David Sucunza, Juan J Vaquero, Obis D Castano, Stanislav Baluschev, Silvia E Angelova
Beilstein J Org Chem. 2017 Dec 28;13:2902-2914. doi: 10.3762/bjoc.13.283.
Recent Advances in the Synthesis of Azonia Aromatic Heterocycles.
David Sucunza, Ana M Cuadro, Julio Alvarez-Builla, Juan J Vaquero
J Org Chem. 2016 Nov 4;81(21):10126-10135. doi: 10.1021/acs.joc.6b01092. Epub 2016 Jul 18.
Synthesis of 1-Substituted Isoquinolines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Cassiarin A.
Sara Gutierrez, Anna Coppola, David Sucunza, Carolina Burgos, Juan J Vaquero
Org Lett. 2016 Jul 15;18(14):3378-81. doi: 10.1021/acs.orglett.6b01521. Epub 2016 Jun 28.
Highly Fluorescent Green Fluorescent Protein Chromophore Analogues Made by Decorating the Imidazolone Ring.
Sara Gutierrez, David Martinez-Lopez, Maria Moron, David Sucunza, Diego Sampedro, Alberto Domingo, Antonio Salgado, Juan J Vaquero
Chemistry. 2015 Dec 14;21(51):18758-63. doi: 10.1002/chem.201502929. Epub 2015 Nov 3.
Assembly of New Merocyanine Chromophores with a 1,8-Naphthalimide Core by a New Method for the Synthesis of the Methine Function.
Aleksey A. Vasilev, Stanislav Baluschev, Diana Cheshmedzhieva, Sonia Ilieva, Obis D. Castaño, Juan J Vaquero, Silvia E. Angelova, Katharina Landfester
Australian Journal of Chemistry. 2015 Aug 25; :1399-1408.
Nonlinear Emission of Quinolizinium Based Dyes With Application in Fluorescence Lifetime Imaging.
Gema Marcelo, Sandra Pinto, Tatiana Cañeque, Inês F. A. Mariz, Ana M. Cuadro, Juan J Vaquero, José M. G. Martinho, Ermelinda M. S. Maçôas
The Journal of Physical Chemistry A. 2015 Aug 18; :2351-2362.
Azonia Aromatic Cations by Ring-Closing Metathesis: Synthesis ofAzaquinolizinium Cations.
Alberto Abengozar, Beatriz Abarca, Ana M. Cuadro, David Sucunza, Julio Álvarez‐Builla, Juan J Vaquero
Eur J Org Chem. 2015 Jun 24; 6(24):4214-4223.
Synthesis and biological evaluation of pyridazino%1′,6′:1,2%pyrido%3,4-b%indolinium and pyridazino%1,6-a%benzimidazolium salts as anti-inflammatory agents.
Aranzazu Rodríguez-Sanz, Patricia Sánchez-Alonso, Teresa Bellón, Ramón Alajarín, Virginia Martínez-Cabeza, Rafael Selgas, Juan J. Vaquero, Julio Álvarez-Builla
Eur. J. Med. Chem. 2015 Mar; :83-92.
Isoquinoline synthesis by heterocyclization of tosylmethyl isocyanide derivatives: total synthesis of mansouramycin B.
Anna Coppola, David Sucunza, Carolina Burgos, Juan J Vaquero
Org Lett. 2015 Jan 2;17(1):78-81. doi: 10.1021/ol5032624. Epub 2014 Dec 18.
Targeting DNA with small molecules: a comparative study of a library of azonia aromatic chromophores.
Rosa M Suarez, Pedro Bosch, David Sucunza, Ana M Cuadro, Alberto Domingo, Francisco Mendicuti, Juan J Vaquero
Org Biomol Chem. 2015 Jan 14;13(2):527-38. doi: 10.1039/c4ob01465k. Epub 2014 Nov 7.
Efficient synthesis of an indoloquinolizinium alkaloid selective DNA-binder by ring-closing metathesis.
Beatriz Abarca, Raul Custodio, Ana M Cuadro, David Sucunza, Alberto Domingo, Francisco Mendicuti, Julio Alvarez-Builla, Juan J Vaquero
Org Lett. 2014 Jul 3;16(13):3464-7. doi: 10.1021/ol5013668.
Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold.
Ana I Sanchez, Ricardo Meneses, Jose M Minguez, Araceli Nunez, Rafael R Castillo, Fabiana Filace, Carolina Burgos, Juan J Vaquero, Julio Alvarez-Builla, Alvaro Cortes-Cabrera, Federico Gago, Emma Terricabras, Victor Segarra
Org Biomol Chem. 2014 Jun 28;12(24):4233-42. doi: 10.1039/c4ob00175c.
Cucurbit%n%urils as a potential fine-tuned instrument for modifying photophysical properties of D–π–A+–π–D “push–pull” chromophores.
Thais Carmona, Tatiana Cañeque, Raul Custodio, Ana M. Cuadro, Juan J Vaquero, Francisco Mendicuti
Dyes and Pigments. 2014 Apr 1; :106-117. doi: 10.1016/j.dyepig.2013.12.003
Novel charged NLO chromophores based on quinolizinium acceptor units.
Tatiana Cañeque, Ana M. Cuadro, Julio Alvarez-Builla, Julio Alvarez-Builla, Javier Pérez-Moreno, Koen Clays, Obis Castaño, José L. Andrés, Juan J Vaquero
Dyes and Pigments. 2014 Feb 1; :116-121. doi: 10.1016/j.dyepig.2013.09.031
Remote aryl cyanation via isocyanide-cyanide rearrangement on tosylmethyl isocyanide derivatives.
Anna Coppola, Patricia Sanchez-Alonso, David Sucunza, Carolina Burgos, Ramon Alajarin, Julio Alvarez-Builla, Marta E G Mosquera, Juan J Vaquero
Org Lett. 2013 Jul 5;15(13):3388-91. doi: 10.1021/ol401433x.
A cascade reaction of azolopyrimidines. Synthesis of unusual indole and azaindole derivatives.
María Morón, Carolina Burgos, Julio Alvarez-Builla, Antonio Salgado, Marta E. G. Mosquera, Juan J Vaquero
Chem. Commun. 2012 Jul 23;48:9171–9173. doi: 10.1039/c2cc34539k.
Superior Neuroprotective Efficacy of LAU-0901, a Novel Platelet-Activating Factor Antagonist, in Experimental Stroke.
Ludmila Belayev, Tiffany N. Eady, Larissa Khoutorova, Kristal D. Atkins, Andre Obenaus, Marta Cordoba, Juan J. Vaquero, Julio Alvarez-Builla, Nicolas G. Bazan
Translational Stroke Research 2012; 3(1):154 -163. doi: 10.1007/s12975-011-0116-y
Synthesis of 9,9′-%1,2-Ethanediylbis(oxymethylene)%bis-2-amino-1,9-dihydro-6H-purin-6-one, an Impurity of Acyclovir.
Rosa M. Suárez, Maria Paz Matía, José Luis Novella, Andres Molina, Antonio Cosme, Juan José Vaquero, Julio Alvarez-Builla
Molecules. 2012; 17(8). doi: 10.3390/molecules17088735
New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers
Gonzalo García, Isabel Serrano, Patricia Sánchez-Alonso, Manuel Rodríguez-Puyol, Ramón Alajarín, Mercedes Griera, Juan J. Vaquero, Diego Rodríguez-Puyol, Julio Álvarez-Builla, María L. Díez-Marqués
Eur. J. Med. Chem 2012; 50:90 -101. doi: 10.1016/j.ejmech.2012.01.043.
Radical Intramolecular Arylation of Pyridinium Salts: A Straightforward Entry to 7-Hydroxypyrido%2,1‐a%isoquinolinylium Salts /
Rafael R. Castillo, Carolina Burgos, Juan J. Vaquero, Julio Alvarez-Builla
European Journal of Organic Chemistry. 2011; 2011(3):619-628. doi: 10.1002/ejoc.201001071
An environmentally benign procedure for the synthesis of substituted 2-thiobenzothiazoles, 2-thiobenzoxazoles, 2-thiobenzimidazoles, and 1,3-oxazolopyridine-2-thiols.
Todor G. Deligeorgiev, Stefka S. Kaloyanova, Nedyalko Y. Lesev, Juan J. Vaquero
Monatsh. Chem. 2011; 142(9):895. doi: 10.1007/s00706-011-0551-1
Synthesis of novel tetracationic asymmetric monomeric monomethine cyanine dyes – highly fluorescent dsDNA probes /
Aleksey Vasilev, Todor Deligeorgiev, Stefka Kaloyanova, Stanimir Stoyanov, Vera Maximova, Juan J Vaquero, Julio Alvarez-Builla
Coloration Technology. 2011; 127(1):69-74. doi: 10.1111/j.1478-4408.2010.00280.x
Environmental Risk Assessment of Emerging Pollutants in Water: Approaches Under Horizontal and Vertical EU Legislation /
M. D. Hernando, A. Rodríguez, J. J. Vaquero, A. R. Fernández-Alba, E. García
Critical Reviews in Environmental Science and Technology. 2011; 41(7):699-731. doi: 10.1080/10643380903140224
Ring-Closing Metathesis Approach to Heteroaromatic Cations: Synthesis of Benzo%a%Dquinolizinium Salts /
Ana Nuñez, Beatriz Abarca, Ana M. Cuadro, Julio Alvarez-Builla, Juan J. Vaquero
European Journal of Organic Chemistry. 2011; 2011(7):1280 -1290. doi: 10.1002/ejoc.201001373
Heteroaromatic Cation-Based Chromophores: Synthesis and Nonlinear Optical Properties of Alkynylazinium Salts /
Tatiana Cañeque, Ana M. Cuadro, Julio Alvarez-Builla, Javier Pérez-Moreno, Koen Clays, Gema Marcelo, Francisco Mendicuti, Obis Castaño, José L. Andrés, Juan J. Vaquero
European Journal of Organic Chemistry. 2010; 2010(33):6323-6330. doi: 10.1002/ejoc.201000816
Application of Selective Palladium-Mediated Functionalization of the Pyrido%@5B3′,2′:4,5%@5Dpyrrolo%@5B1,2-c%@5Dpyrimidine Heterocyclic System for the Total Synthesis of Variolin B and Deoxyvariolin B /
Alejandro Baeza, Javier Mendiola, Carolina Burgos, Julio Alvarez-Builla, Juan J. Vaquero
European Journal of Organic Chemistry. 2010; 2010(29):5607-5618. doi: 10.1002/ejoc.201000599
Novel Green Procedure for the Synthesis of 2-Arylbenzothiazoles Under Microwave Irradiation in Peg 200 Or Peg 400 /
Todor G. Deligeorgiev, Stefka Kaloyanova, Aleksey Vasilev, Juan J. Vaquero
Phosphorus, Sulfur, and Silicon and the Related Elements. 2010; 185(11):2292-2302. doi: 10.1080/10426501003598648
Styryl dyes – synthesis and applications during the last 15 years /
Todor Deligeorgiev, Aleksey Vasilev, Stefka Kaloyanova, Juan J Vaquero
Coloration Technology. 2010; 126(2):55-80. doi: 10.1111/j.1478-4408.2010.00235.x
An easy and fast ultrasonic selective S-alkylation of hetaryl thiols at room temperature /
Todor Deligeorgiev, Stefka Kaloyanova, Nedyalko Lesev, Juan J. Vaquero
Ultrasonics Sonochemistry 2010; 17(5):783-788. doi: 10.1016/j.ultsonch.2010.03.002